dc.contributor.author | HERGENC, Gulay | |
dc.contributor.author | ONAT, Altan | |
dc.contributor.author | SARI, Ibrahim | |
dc.contributor.author | Can, Günay | |
dc.contributor.author | YAZICI, Mehmet | |
dc.contributor.author | Eryonucu, Beyhan | |
dc.date.accessioned | 2021-03-05T20:58:20Z | |
dc.date.available | 2021-03-05T20:58:20Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | HERGENC G., ONAT A., SARI I., YAZICI M., Eryonucu B., Can G., "Serum total and high-density lipoprotein phospholipid levels in a population-based study and relationship to risk of metabolic syndrome and coronary disease", ANGIOLOGY, cilt.59, ss.26-35, 2008 | |
dc.identifier.issn | 0003-3197 | |
dc.identifier.other | av_d6b3c190-be45-401c-9803-696aec32d52d | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/141682 | |
dc.identifier.uri | https://doi.org/10.1177/0003319706291145 | |
dc.description.abstract | The aim of study was to investigate the role of serum total (TPL) and high-density lipoprotein phospholipids (HDL-pl) as a risk factor in coronary heart disease (CHD) and metabolic syndrome (MS). In a random sample, total and HDL-pI were measured in 1088 and 642 adults from Turkey, respectively, who have a high prevalence of MS; this was done with an enzymatic method that measures total phosphatidylcholine, sphingomyelin, and lysophosphatidylcholine. Serum TPL and HDL-pl levels were significantly higher in women (TPL, 2.8 mmol/L; HDL-pl, 1.21 mmol/L) than in men. Strong correlations existed between serum TPL levels and non-HDL cholesterol (HDL-C), triglycerides, apolipoprotein (apo) B, complement C3, and gamma-glutamyltransferase. Non-HDL-C, HDL triglyceride, and apo A-I were strongly correlated with HDL-pl. Linear regression analyses revealed HDL-C, apo B, triglycerides, diabetes, and female gender as independent significant determinants of TPL levels in adults. HDL-C and impaired glucose regulation were sole significant variables, together contributing one-quarter of serum HDL-pl. Individuals with MS or diabetes had significantly higher TPL concentrations. The gender- and age-adjusted odds ratio (OR) of TPL for MS was 1.73 (95% confidence interval, 1.35-2.21), whereas the multiadjusted OR of HDL-pl per 1 SD increment corresponded to a significantly reduced independent MS likelihood by 26% in women (and 18% in the entire group). The multiadjusted OR of HDL-pl for CHD in men and women combined was 0.32 (P =.057) corresponding to a reduced CHD likelihood by 32% per I SD increment of HDL-pl. Plasma TPL levels point to an adverse relationship to MS, whereas their role in CHD risk needs further investigation. HDL-pls, in contrast, mark substantial protection from MS as well as from CHD. | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | PERİFERAL VASKÜLER HASTALIĞI | |
dc.subject | Klinik Tıp | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.title | Serum total and high-density lipoprotein phospholipid levels in a population-based study and relationship to risk of metabolic syndrome and coronary disease | |
dc.type | Makale | |
dc.relation.journal | ANGIOLOGY | |
dc.contributor.department | Turkish Heart Foundation , , | |
dc.identifier.volume | 59 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 26 | |
dc.identifier.endpage | 35 | |
dc.contributor.firstauthorID | 90591 | |