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Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats

dc.contributor.authorKokoglu, E
dc.contributor.authorKavunoglu, G
dc.contributor.authorCansever, S
dc.contributor.authorAltug, T
dc.contributor.authorGorgun, FM
dc.contributor.authorGumustas, MK
dc.date.accessioned2021-03-05T21:02:20Z
dc.date.available2021-03-05T21:02:20Z
dc.date.issued2004
dc.identifier.citationGorgun F., Kokoglu E., Gumustas M., Altug T., Cansever S., Kavunoglu G., "Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, cilt.67, ss.979-986, 2004
dc.identifier.issn1528-7394
dc.identifier.othervv_1032021
dc.identifier.otherav_d701987e-347a-42c6-8697-75cd71579a5f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/141879
dc.identifier.urihttps://doi.org/10.1080/15287390490447278
dc.description.abstractThe aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (CSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significantly decreased plasma GSH but increased the levels of plasma GSNO. Daily supplementation with melatonin restored plasma thiol to control values. Data suggest that STZ-induced hyperglycemia and compounds that act as scavengers of free radicals and peroxynitrite like melatonin may exert protection against STZ-incluced toxicity.
dc.language.isoeng
dc.subjectFarmasötik Toksikoloji
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectÇEVRE BİLİMLERİ
dc.subjectÇevre / Ekoloji
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.titleEffects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats
dc.typeMakale
dc.relation.journalJOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
dc.contributor.department, ,
dc.identifier.volume67
dc.identifier.issue13
dc.identifier.startpage979
dc.identifier.endpage986
dc.contributor.firstauthorID171972


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