The effects of albendazole and povidone iodine for hydatid cysts protoscoleces, in-vitro and -vivo

Abstract

The aim of using chemotherapy for inactivating protoscoleces is to prevent dissemination. The most suitable way to apply chemotherapy is to inject killing substances directly to the hydatid cysts protoscoleces. We performed our experiments with 95% live hydatid cyst protoscoleces. In in-vivo experiments, in survey group mice, no hydatid cyst was observed in the first and second group which 1 g/L and 100 mu g/ml albendazole was added to their waters, respectively and in the third group, 1/10 povidone-iodine was added for 30 min during the 6 months. All of the above groups were given 4 - 6 live hydatid cyst protoscoleces. However, hydatid cysts were developed in the control group mice in the 87th day. In in-vitro studies; all of the hydatid cysts pre-treated with 1/10 povidone-iodine and 100 mu g/ml albendazole lost their viability after 15 min and the viability of the hydatid cysts, which were kept at room temperature were not lost.