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dc.contributor.authorKiremitci, Abdurrahman
dc.contributor.authorOz, Yasemin
dc.contributor.authorKiraz, Nuri
dc.contributor.authorMetintas, Selma
dc.contributor.authorDag, Ilknur
dc.date.accessioned2021-03-05T21:25:43Z
dc.date.available2021-03-05T21:25:43Z
dc.date.issued2013
dc.identifier.citationOz Y., Kiremitci A., Dag I., Metintas S., Kiraz N., "Postantifungal effect of the combination of caspofungin with voriconazole and amphotericin B against clinical Candida krusei isolates", MEDICAL MYCOLOGY, cilt.51, ss.60-65, 2013
dc.identifier.issn1369-3786
dc.identifier.otherav_d8cb6f7d-045b-4ff7-aa2a-06f296a3d332
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/143029
dc.identifier.urihttps://doi.org/10.3109/13693786.2012.697198
dc.description.abstractWe evaluated the postantifungal effects (PAFEs) of caspofungin (CAS), voriconazole (VOR), amphotericin B (AmB), and the combinations of CAS + VOR and CAS + AmB against 30 clinical Candida krusei isolates at 0.25, 1 and 4 times the MIC of each individually and in the indicated combinations. Antifungals were removed after 1 hour and colony counts were performed at 0, 2, 6, 24, and 48 h. VOR did not display any measurable PAFE regardless of antifungal concentrations, while AmB and CAS exhibited dose-dependent PAFE. The most effective agent producing a prolonged PAFE in this study was CAS. Although the combination of CAS with VOR generated longer PAFEs at 0.25 and 1 times their respective MICs in comparison with CAS alone, this combination was indifferent rather than synergistic. However, the combination of CAS with AmB at 4 times their MICs exhibited the best performance, reducing the colony counts during the 48 h after removal of drugs and resulted in synergic interaction in respect to 20 (67%) isolates. Consequently, CAS has a prolonged PAFE in vitro against C. krusei isolates, and the combination of AmB + CAS may increase significantly the efficacy of CAS. Our data may be useful in optimizing dosing regimens for these agents and their combinations, although further studies are needed to explore the clinical usefulness of our results.
dc.language.isoeng
dc.subjectVeteriner Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectMikoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectVETERİNERLİK BİLİMLERİ
dc.subjectSağlık Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectMİKOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.subjectBULAŞICI HASTALIKLAR
dc.titlePostantifungal effect of the combination of caspofungin with voriconazole and amphotericin B against clinical Candida krusei isolates
dc.typeMakale
dc.relation.journalMEDICAL MYCOLOGY
dc.contributor.departmentEskişehir Osmangazi Üniversitesi , ,
dc.identifier.volume51
dc.identifier.issue1
dc.identifier.startpage60
dc.identifier.endpage65
dc.contributor.firstauthorID36160


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