Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer
Tarih
2012Yazar
Nakai, Shiro
Tuncel, Handan
Jikihara, Hiroshi
Takata, Takashi
Tatsuka, Masaaki
Shimamoto, Fumio
Kaneko, Hiroshi
Kaneko, Hiroshi (Guangying Qi)
Aoki, Eriko
Üst veri
Tüm öğe kaydını gösterÖzet
The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis, and consists of Aurora B kinase, INCENP, Survivin and Borealin. Aurora B is a member of a family of serine/threonine protein kinases, and Survivin belongs to the inhibitors of apoptosis (IAP) gene family, and is also a member of the CPC family. Aurora B and Survivin have also been reported to be overexpressed in various human cancers; however, as yet no studies have investigated the co-expression of Survivin and Aurora B in colorectal carcinoma. Therefore, in the present study, the correlation between Aurora B and Survivin expression was investigated using immunohistochemistry and the associated pathological features in colorectal carcinoma were analyzed. Our present findings showed that nuclear Aurora B and cytoplasmic Survivin expression are strongly associated with and involved in lymph node metastasis in colorectal cancer. Therefore, we suggest that nuclear Aurora B and cytoplasmic Survivin are useful diagnostic markers and therapeutic targets in colorectal carcinoma.
Koleksiyonlar
- Makale [92796]