dc.contributor.author | Deser, Serkan Burc | |
dc.contributor.author | Gode, Safa | |
dc.contributor.author | Cengiz, Mujgan | |
dc.contributor.author | Arapi, Berk | |
dc.contributor.author | Bayoglu, Burcu | |
dc.contributor.author | Dirican, Ahmet | |
dc.contributor.author | Dagistanli, Fatma Kaya | |
dc.contributor.author | Arslan, Caner | |
dc.date.accessioned | 2021-03-02T22:29:51Z | |
dc.date.available | 2021-03-02T22:29:51Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Bayoglu B., Arslan C., Gode S., Dagistanli F. K. , Arapi B., Deser S. B. , Dirican A., Cengiz M., "The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression", JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.21, sa.7, ss.659-671, 2014 | |
dc.identifier.issn | 1340-3478 | |
dc.identifier.other | av_0d07bb3a-9c01-4c51-ab47-e7b27ab4b427 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/14367 | |
dc.identifier.uri | https://doi.org/10.5551/jat.21774 | |
dc.description.abstract | Aim: The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression in vascular smooth muscle cells (VSMCs) and may modulate the early stages of atherosclerosis. Therefore, we aimed to study the expression of the INK4/ARF locus genes CDKN2A and CDKN2BAS in order to examine the p16INK4a protein expression and the level of cell proliferation in carotid plaques and saphenous tissue samples. | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp | |
dc.subject | PERİFERAL VASKÜLER HASTALIĞI | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.title | The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 21 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 659 | |
dc.identifier.endpage | 671 | |
dc.contributor.firstauthorID | 81042 | |