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dc.contributor.authorDeser, Serkan Burc
dc.contributor.authorGode, Safa
dc.contributor.authorCengiz, Mujgan
dc.contributor.authorArapi, Berk
dc.contributor.authorBayoglu, Burcu
dc.contributor.authorDirican, Ahmet
dc.contributor.authorDagistanli, Fatma Kaya
dc.contributor.authorArslan, Caner
dc.date.accessioned2021-03-02T22:29:51Z
dc.date.available2021-03-02T22:29:51Z
dc.date.issued2014
dc.identifier.citationBayoglu B., Arslan C., Gode S., Dagistanli F. K. , Arapi B., Deser S. B. , Dirican A., Cengiz M., "The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression", JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.21, sa.7, ss.659-671, 2014
dc.identifier.issn1340-3478
dc.identifier.otherav_0d07bb3a-9c01-4c51-ab47-e7b27ab4b427
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14367
dc.identifier.urihttps://doi.org/10.5551/jat.21774
dc.description.abstractAim: The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression in vascular smooth muscle cells (VSMCs) and may modulate the early stages of atherosclerosis. Therefore, we aimed to study the expression of the INK4/ARF locus genes CDKN2A and CDKN2BAS in order to examine the p16INK4a protein expression and the level of cell proliferation in carotid plaques and saphenous tissue samples.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.titleThe Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression
dc.typeMakale
dc.relation.journalJOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume21
dc.identifier.issue7
dc.identifier.startpage659
dc.identifier.endpage671
dc.contributor.firstauthorID81042


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