Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders

Date
2011
Author
de Seze, Jerome
Paul, Friedemann
Rommer, Paulus
Mader, Simone
Kleiter, Ingo
Reindl, Markus
Seifert-Held, Thomas
Kristoferitsch, Wolfgang
Melms, Arthur
Wandinger, Klaus-Peter
Wildemann, Brigitte
Akman-Demir, Gulsen
Jarius, Sven
Jacobi, Christian
Zephir, Helene
Franciotta, Diego
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Abstract
Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) and recurrent optic neuritis (rON). However, AQP4-Ab has been found also in patients with co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) or Sjogren's syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation.
URI
http://hdl.handle.net/20.500.12627/144500
https://doi.org/10.1177/1352458511403958
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