dc.contributor.author | Erkan, Melike | |
dc.contributor.author | Yildizbayrak, Nebahat | |
dc.date.accessioned | 2021-03-05T21:57:28Z | |
dc.date.available | 2021-03-05T21:57:28Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Yildizbayrak N., Erkan M., "Acrylamide disrupts the steroidogenic pathway in Leydig cells: possible mechanism of action", TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, cilt.100, ss.235-246, 2018 | |
dc.identifier.issn | 0277-2248 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_db5b11d4-cdad-4f5c-8ca6-285f9adcf7cc | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/144597 | |
dc.identifier.uri | https://doi.org/10.1080/02772248.2018.1458231 | |
dc.description.abstract | Acrylamide-treated Leydig cells were tested for cytotoxicity, testosterone secretion, 3,5-cyclic adenosine monophosphate production, and gene and protein expression of steroidogenic genes and transcription factors. Reverse-transcriptional real-time polymerase chain reaction and western blot analysis revealed that acrylamide disrupts mRNA and protein expression of steroidogenic markers, including luteinizing hormone receptor, steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3-hydroxy dehydrogenase, and 17-hydroxy dehydrogenase. Further, transcription levels of the key regulator transcription factors, steroidogenic factor-1, GATA binding protein-4, and nerve growth factor IB, were evaluated. Acrylamide induced cytotoxicity and decreased testosterone and 3,5-cyclic adenosine monophosphate secretion by altering the rate-limiting steps in Leydig cell steroidogenesis. | |
dc.language.iso | eng | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Mühendislik ve Teknoloji | |
dc.subject | Temel Bilimler | |
dc.subject | TOKSİKOLOJİ | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Çevre Mühendisliği | |
dc.subject | ÇEVRE BİLİMLERİ | |
dc.subject | Çevre / Ekoloji | |
dc.subject | Tarım ve Çevre Bilimleri (AGE) | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Tarımsal Bilimler | |
dc.subject | Meslek Bilimleri | |
dc.subject | Farmasötik Toksikoloji | |
dc.title | Acrylamide disrupts the steroidogenic pathway in Leydig cells: possible mechanism of action | |
dc.type | Makale | |
dc.relation.journal | TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | |
dc.contributor.department | , , | |
dc.identifier.volume | 100 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 235 | |
dc.identifier.endpage | 246 | |
dc.contributor.firstauthorID | 248653 | |