Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey
Date
2003Author
Timur, C
Sirma, S
Devecioglu, O
Meral, A
Gedikoglu, G
Ozbek, U
Agaoglu, L
Yuksel, L
Anak, S
Yildiz, I
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Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.
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