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dc.contributor.authorAktan, Gülşen
dc.contributor.authorKocak-Toker, N
dc.contributor.authorAYKAC-TOKER, G
dc.date.accessioned2021-03-06T07:43:39Z
dc.date.available2021-03-06T07:43:39Z
dc.date.issued2002
dc.identifier.citationKocak-Toker N., Aktan G., AYKAC-TOKER G., "The role of Na,K-ATPase in human sperm motility", INTERNATIONAL JOURNAL OF ANDROLOGY, cilt.25, ss.180-185, 2002
dc.identifier.issn0105-6263
dc.identifier.otherav_dd96fc02-7246-48be-9c9b-6bc531e342dc
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/146002
dc.identifier.urihttps://doi.org/10.1046/j.1365-2605.2002.00346.x
dc.description.abstractA fourth Na,K-ATPase alpha isoform, which was found to be abundant in testes, was proved to be a catalytical subunit of the enzyme. Recently, it has been shown that the alpha 4 isoform along with alpha 1 is expressed in the midpiece of the flagellum of mature rat sperm and the inhibition of alpha 4 with ouabain led to sperm immotility. In this study, sperm from 135 males with normal semen profile and 50 males with oligoasthenospermia were treated with 10(-5) and 10(-2) M ouabain solutions to inhibit alpha 4, and alpha 4 plus alpha 1 isoforms, respectively. In males with normal semen profile, sperm motility has been demonstrated to decrease with time to almost the same level with both ouabain solutions. In oligoasthenospermic males motility was also found almost completely lost. These observations showed us that the alpha 4 isoform may be held responsible for human sperm motility.
dc.language.isoeng
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectTıp
dc.subjectİç Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectANDROLOJİ
dc.titleThe role of Na,K-ATPase in human sperm motility
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF ANDROLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume25
dc.identifier.issue3
dc.identifier.startpage180
dc.identifier.endpage185
dc.contributor.firstauthorID16960


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