Association of APOE polymorphisms with disease severity in MS is limited to women
Date
2004Author
de Andrade, M
Weinshenker, BG
Atkinson, EJ
McMurray, CT
Rodriguez, M
Kantarci, OH
Hebrink, DD
Achenbach, SJ
Pittock, SJ
Altintas, A
Schaefer-Klein, JL
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Show full item recordAbstract
The authors studied the association of an exon 4 (E4* epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4* epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 ( p = 0.015) and had more favorable ranked severity scores than noncarriers ( p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.
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