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dc.contributor.authorOzkara, Hamdi
dc.contributor.authorALICI, Bulent
dc.contributor.authorAydemir, Birsen
dc.contributor.authorOnaran, Ilhan
dc.contributor.authorAkyolcu, Mehmet Can
dc.contributor.authorKIZILER, Ali Rıza
dc.date.accessioned2021-03-02T22:36:57Z
dc.date.available2021-03-02T22:36:57Z
dc.date.issued2006
dc.identifier.citationAydemir B., KIZILER A. R. , Onaran I., ALICI B., Ozkara H., Akyolcu M. C. , "Impact of cu and Fe concentrations on oxidative damage in male infertility", BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.112, sa.3, ss.193-203, 2006
dc.identifier.issn0163-4984
dc.identifier.othervv_1032021
dc.identifier.otherav_0da7c5bd-a5dd-4761-a12a-9b744e0b45dc
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14766
dc.identifier.urihttps://doi.org/10.1385/bter:112:3:193
dc.description.abstractOxidative stress in the reproductive system is thought to have an effect on the fertilizing ability of sperm. The purpose of this study was to assess the interaction of iron (Fe) and copper (Cu) ions in suspected subfertile and fertile male groups and to find out the relationships of the semen parameters (sperm count, motility, and abnormal morphology), glutathione, malondialdehyde, and reactive oxygen species with these variables. Semen and blood obtained from 60 subfertile men and from 40 fertile volunteers were examined. The sperm count and motility in the subfertile male group were found lower than those in fertile male group (p < 0.001). Cu levels in serum and seminal plasma in the subfertile male group were significantly higher than those in the fertile male group (p < 0.001 and p < 0.05, respectively). There was also a significant increase in the Fe level of seminal plasma in the subfertile male group (p < 0.001). However, there was no significant difference in the Fe level of serum in the subfertile male group. In conclusion, these findings suggest that Cu and Fe might be mediators of the effects of oxidative damage and play an essential role in spermatogenesis and male infertility; the determination of Fe and Cu levels in serum and seminal plasma during infertility investigation is recommended.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTemel Bilimler
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.titleImpact of cu and Fe concentrations on oxidative damage in male infertility
dc.typeMakale
dc.relation.journalBIOLOGICAL TRACE ELEMENT RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume112
dc.identifier.issue3
dc.identifier.startpage193
dc.identifier.endpage203
dc.contributor.firstauthorID6801


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