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dc.contributor.authorTuran, Selin
dc.contributor.authorYalcinkaya, Nazli
dc.contributor.authorTuzun, Erdem
dc.contributor.authorHanagasi, Haşmet Ayhan
dc.contributor.authorCakir, Sibel
dc.contributor.authorUlusoy, Canan
dc.contributor.authorCoban, Arzu
dc.contributor.authorKucukali, Cem Ismail
dc.contributor.authorUcok, Alp
dc.contributor.authorUNUBOL, Huseyin
dc.contributor.authorHaytural, Hazal
dc.contributor.authorBilgic, Başar
dc.contributor.authorGurvit, Hakan
dc.date.accessioned2021-03-02T22:37:25Z
dc.date.available2021-03-02T22:37:25Z
dc.identifier.citationCoban A., Kucukali C. I. , Bilgic B., Yalcinkaya N., Haytural H., Ulusoy C., Turan S., Cakir S., Ucok A., UNUBOL H., et al., "Evaluation of incidence and clinical features of antibody-Associated autoimmune encephalitis mimicking dementia", Behavioural Neurology, cilt.2014, 2014
dc.identifier.issn0953-4180
dc.identifier.othervv_1032021
dc.identifier.otherav_0db44c8e-dbfa-4df6-a15c-c8b2c3e6880f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14801
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898620714&origin=inward
dc.identifier.urihttps://doi.org/10.1155/2014/935379
dc.description.abstractAnti-neuronal autoimmunity may cause cognitive impairment that meets the criteria for dementia. Objective. Our aim was to detect the incidence and clinical features of autoimmune encephalitis imitating clinical findings of primary dementia disorders and to delineate the validity of anti-neuronal antibody screening in dementia patients. Methods. Fifty consecutive patients fulfilling the clinical criteria for primary dementia, 130 control patients, and 50 healthy controls were included. Their sera were investigated for several ion channel and glutamic acid decarboxylase (GAD) antibodies by a cell-based assay, radioimmunoassay, and ELISA, as required. Results. Sixteen patients satisfying dementia criteria had atypical findings or findings suggestive of autoimmune encephalitis. N-methyl-D-Aspartate receptor (NMDAR) antibody was detected in a patient with dementia, Parkinsonism, and REM sleep behavior disorder (RBD) fulfilling the criteria for dementia with Lewy bodies (DLB). One control patient with bipolar disease displayed low anti-GAD antibody levels. Conclusions. Our study showed for the first time the presence of parkinsonism and RBD in an anti-NMDAR encephalitis patient mimicking DLB. Although autoimmune encephalitis patients may occasionally present with cognitive decline, most dementia patients do not exhibit anti-neuronal antibodies, suggesting that routine analysis of these antibodies in dementia is not mandatory, even though they display atypical features. Copyright © 2014 Giovanni A.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.titleEvaluation of incidence and clinical features of antibody-Associated autoimmune encephalitis mimicking dementia
dc.typeMakale
dc.relation.journalBehavioural Neurology
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume2014
dc.contributor.firstauthorID38503


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