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dc.contributor.authorOlgac, V.
dc.contributor.authorCakarer, Sırmahan
dc.contributor.authorKeskin, C.
dc.contributor.authorAksakalli, N.
dc.contributor.authorTang, Andrew
dc.date.accessioned2021-03-02T22:37:54Z
dc.date.available2021-03-02T22:37:54Z
dc.date.issued2010
dc.identifier.citationCakarer S., Olgac V., Aksakalli N., Tang A., Keskin C., "Acceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats", BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, cilt.48, sa.8, ss.633-636, 2010
dc.identifier.issn0266-4356
dc.identifier.othervv_1032021
dc.identifier.otherav_0dc3a38c-9721-48fc-80d6-98619aa8436b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14838
dc.identifier.urihttps://doi.org/10.1016/j.bjoms.2009.11.009
dc.description.abstractWe aimed to find out whether a single local injection of two different doses of thrombin peptide 508 (TP508) could accelerate consolidation of bone in sites of tibial distraction osteogenesis in rats. Forty-eight adult male Sprague Dawley rats were divided equally (n = 16 in each group) into controls (given saline alone), and two experimental groups, given injections of TP508 10 mu g or 100 mu g. The animals were killed on days 14 and 28 after distraction. Histomorphometric evaluation showed that the TP508 resulted in significantly larger areas of newly formed bone (p < 0.003 and p < 0.0001) than saline alone. At 2 weeks, more new bone had formed in the group given TP508 100 jig than in the group given 10 mu g, but the difference was not significant (p = 0.8). However, the difference was significant at 4 weeks (p = 0.03). These findings suggest that a single injection of TP508 given at the end of the distraction period increased the degree of consolidation. The higher dose was more effective at the later time point. (C) 2009 The British Association of Oral and Maxillofacial Surgeons. All rights reserved.
dc.language.isoeng
dc.subjectCerrahi Tıp Bilimleri
dc.subjectDiş Hekimliği
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectCERRAHİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.titleAcceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats
dc.typeMakale
dc.relation.journalBRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
dc.contributor.departmentTarga Therapeut , ,
dc.identifier.volume48
dc.identifier.issue8
dc.identifier.startpage633
dc.identifier.endpage636
dc.contributor.firstauthorID81430


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