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dc.contributor.authorTsoukalas, Dimitrios
dc.contributor.authorSpandidos, Demetrios A.
dc.contributor.authorKotil, Tugba
dc.contributor.authorOzcagli, Eren
dc.contributor.authorKara, Mehtap
dc.contributor.authorAlpertunga, Buket
dc.contributor.authorTsatsakis, Aristides M.
dc.contributor.authorFragkiadaki, Persefoni
dc.contributor.authorTzatzarakis, Manolis N.
dc.contributor.authorTSITSIMPIKOU, Christina
dc.contributor.authorStivaktakis, Polychronis D.
dc.date.accessioned2021-03-06T08:46:19Z
dc.date.available2021-03-06T08:46:19Z
dc.date.issued2018
dc.identifier.citationOzcagli E., Kara M., Kotil T., Fragkiadaki P., Tzatzarakis M. N. , TSITSIMPIKOU C., Stivaktakis P. D. , Tsoukalas D., Spandidos D. A. , Tsatsakis A. M. , et al., "Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, cilt.42, ss.405-413, 2018
dc.identifier.issn1107-3756
dc.identifier.otherav_e289dd5e-b6a3-4c66-b042-2647a2b44b18
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/149114
dc.identifier.urihttps://doi.org/10.3892/ijmm.2018.3644
dc.description.abstractAnabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17-alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the most well recognized target organ. In the present study, the hepatic effects of stanozolol administration in rats at high doses resembling those used for doping purposes were investigated, in the presence or absence of exercise. Stanozolol and its metabolites, 16--hydroxystanozolol and 3-hydroxystanozolol, were detected in rat livers using liquid chromatography-mass spectrometry (LC-MS). Telomerase activity, which is involved in cellular aging and tumorigenesis, was detected by examining telomerase reverse transcriptase (TERT) and phosphatase and tensin homolog (PTEN) expression levels in the livers of stanozolol-treated rats. Stanozolol induced telomerase activity at the molecular level in the liver tissue of rats and exercise reversed this induction, reflecting possible premature liver tissue aging. PTEN gene expression in the rat livers was practically unaffected either by exercise or by stanozolol administration.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.titleStanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
dc.contributor.departmentUniversity Of Crete , ,
dc.identifier.volume42
dc.identifier.issue1
dc.identifier.startpage405
dc.identifier.endpage413
dc.contributor.firstauthorID14755


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