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dc.contributor.authorTUĞRUL, HAMDİ MURAT
dc.contributor.authorAktas, Zerrin
dc.contributor.authorUnlu, Ozge
dc.date.accessioned2021-03-02T22:39:02Z
dc.date.available2021-03-02T22:39:02Z
dc.date.issued2018
dc.identifier.citationUnlu O., Aktas Z., TUĞRUL H. M. , "Analysis of Virulence Factors and Antimicrobial Resistance in Salmonella Using Molecular Techniques and Identification of Clonal Relationships Among the Strains", MICROBIAL DRUG RESISTANCE, cilt.24, sa.10, ss.1475-1482, 2018
dc.identifier.issn1076-6294
dc.identifier.othervv_1032021
dc.identifier.otherav_0de24b56-99f5-4a4b-a5c2-0d364bcf3b49
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14923
dc.identifier.urihttps://doi.org/10.1089/mdr.2018.0042
dc.description.abstractA total of 50 Salmonella enterica strains were isolated from clinical samples from 2009 to 2012 and analyzed for the presence of virulence genes found in SPI-1, SPI-2, and plasmids. The distribution and frequency of the antimicrobial resistance genes and plasmids were revealed, and pulsed-field gel electrophoresis (PFGE) patterns were investigated. Five genes were identified from the seven strains with resistance or intermediate resistance to ampicillin: blaSHV-1 (present in six strains), qnrS1 (present in five strains), blaTEM-1 (present in three strains), blaCTX-M-1 (present in one strain), and qnrB1 (present in one strain). One trimethoprim-sulfamethoxazole-resistant strain was positive for sulI but negative for sulII. In addition, we detected TEM-1 and qnrS1 in one strain; SHV-1 and qnrS1 in two strains; TEM-1, SHV-1, CTX-M-1, and qnrS1 in one strain; TEM-1, SHV-1, and qnrB1 in one strain; and SHV-1 and sulI genes in one strain together. Plasmid-based replicon typing assay revealed that all 50 strains carried FIIS, 13 carried I1, 1 carried I2, 4 carried P, 1 carried A/C, and 4 carried X1 replicon. PFGE was used to type 46 of the 50 strains and classify them into 22 major groups, 33 pulsotypes, and 8 major clusters. All strains carried all the virulence genes of interest on both Salmonella Pathogenicity Islands 1 and 2 and plasmids suggested high potential for pathogenicity. All antimicrobial-resistant strains contained at least one of the resistance genes of interest, confirming a phenotype-genotype association in antimicrobial resistance.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.titleAnalysis of Virulence Factors and Antimicrobial Resistance in Salmonella Using Molecular Techniques and Identification of Clonal Relationships Among the Strains
dc.typeMakale
dc.relation.journalMICROBIAL DRUG RESISTANCE
dc.contributor.departmentBeykent Üniversitesi , ,
dc.identifier.volume24
dc.identifier.issue10
dc.identifier.startpage1475
dc.identifier.endpage1482
dc.contributor.firstauthorID253519


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