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dc.contributor.authorGuven, Mehmet
dc.contributor.authorDomaniç, Nergiz
dc.contributor.authorGuven, Gülgün
dc.contributor.authorOzaydin, Ahmet
dc.contributor.authorBatar, Bahadır
dc.contributor.authorHacihanefioglu, Seniba
dc.contributor.authorÖz, Erdinç
dc.contributor.authorUlutin, Turgut
dc.date.accessioned2021-03-06T09:07:46Z
dc.date.available2021-03-06T09:07:46Z
dc.date.issued2007
dc.identifier.citationGuven M., Guven G., Öz E., Ozaydin A., Batar B., Ulutin T., Hacihanefioglu S., Domaniç N., "DNA repair gene XRCC1 and XPD polymorphisms and their association with coronary artery disease risks and micronucleus frequency", HEART AND VESSELS, cilt.22, ss.355-360, 2007
dc.identifier.issn0910-8327
dc.identifier.othervv_1032021
dc.identifier.otherav_e436731b-3af4-420d-8de5-b89662bae57a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/150170
dc.identifier.urihttps://doi.org/10.1007/s00380-007-0986-9
dc.description.abstractCoronary artery disease (CAD) is a multifactorial process that appears to be caused by the interaction of environmental risk factors with multiple predisposing genes. In this study, we investigated the effects of the XPD Lys751Gln and XRCC1 Arg399Gln polymorphisms on the presence and the severity of CAD. We also investigated the presence of DNA damage in the peripheral lymphocytes of patients with CAD by using the micronucleus (MN) test and the effect of XPD Lys751Gln and XRCC1 Arg399Gln polymorphisms on this damage. The study population consisted of 147 patients with angiographically documented CAD and 48 healthy controls. No association between XPD Lys751Gln or XRCC1 Arg399Gln polymorphisms and the presence or the severity of CAD was observed. On the other hand, a significantly higher frequency of MN was observed in CAD patients compared with controls (5.7 +/- 1.9 vs 5.0 +/- 2.1, respectively, P = 0.018). We found an elevated frequency of MN in CAD patients with the XPD 751Gln allele (Gln/Gln genotype) or the XRCC1 399Gln (Arg/Gln or Gln/Gln genotypes) allele compared with the XPD 751Lys (Lys/Lys genotype) allele or XRCC1 399 Arg (Arg /Arg genotype) allele, respectively. These preliminary results suggest that XPD Lys751Gln and XRCC1 Arg399Gln polymorphisms may not be a significant risk factor for developing CAD. In addition, our results indicate that the MN frequency is associated with presence, but not severity, of CAD and is related to the XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms, suggesting an elevated frequency of MN in CAD patients with the XPD 751Gln or XRCC1 399Gln alleles.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectKardiyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCARDIAC ve CARDIOVASCULAR SİSTEMLER
dc.titleDNA repair gene XRCC1 and XPD polymorphisms and their association with coronary artery disease risks and micronucleus frequency
dc.typeMakale
dc.relation.journalHEART AND VESSELS
dc.contributor.department, ,
dc.identifier.volume22
dc.identifier.issue6
dc.identifier.startpage355
dc.identifier.endpage360
dc.contributor.firstauthorID54420


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