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dc.contributor.authorGUMUSTAS, Mustafa Koray
dc.contributor.authorATUKEREN, Pınar
dc.contributor.authorDemirci, Cihan
dc.contributor.authorCETINKAYA, H
dc.contributor.authorKandil, ASLI
dc.contributor.authorGARGILI, Ayşen
dc.date.accessioned2021-03-06T09:37:53Z
dc.date.available2021-03-06T09:37:53Z
dc.date.issued2004
dc.identifier.citationGARGILI A., Demirci C., Kandil A., CETINKAYA H., ATUKEREN P., GUMUSTAS M. K. , "In vivo inhibition of inducible nitric oxide and evaluation of the brain tissue damage induced by Toxocara canis larvae in experimentally infected mice", CHINESE JOURNAL OF PHYSIOLOGY, cilt.47, ss.189-196, 2004
dc.identifier.issn0304-4920
dc.identifier.othervv_1032021
dc.identifier.otherav_e6667b59-9b6a-4b46-ab50-4db3e594bf77
dc.identifier.urihttp://hdl.handle.net/20.500.12627/151563
dc.description.abstractNitric oxide (NO) is known to be produced by macrophages, endothelial cells and neurons and synthesized by an enzyme called nitric oxide synthase (NOS). Various effector mechanisms and infections can affect the NO production. Excessive amount of NO will lead to biochemical reactions, which cause toxic effects. In this study the role of NO has been evaluated in larval toxocarosis, which is a systemic parasite infection caused by T. canis larvae. Infection was established in the Balb/c mice with or without inducible NOS (iNOS) inhibition and the effects of infection and NOS inhibition were observed according to the results of SOD and LPx measurements in brain tissue and NADPH-diaphorase (NADP-d) histochemistry. Results of NADPH-d histochemistry indicate that iNOS inhibition has protective effect on the brains of infected mice and that larval T. canis infection could be related to oxidative stress, and NO production and iNOS inhibition can protect the tissue from damage in this infection.
dc.language.isoeng
dc.subjectFizyoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBiyoloji ve Biyokimya
dc.subjectFİZYOLOJİ
dc.titleIn vivo inhibition of inducible nitric oxide and evaluation of the brain tissue damage induced by Toxocara canis larvae in experimentally infected mice
dc.typeMakale
dc.relation.journalCHINESE JOURNAL OF PHYSIOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume47
dc.identifier.issue4
dc.identifier.startpage189
dc.identifier.endpage196
dc.contributor.firstauthorID31333


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