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Genetic evidence for the involvement of Fc gamma receptor III in experimental autoimmune myasthenia gravis pathogenesis

dc.contributor.authorAlagappan, Dhivyaa
dc.contributor.authorTuzun, Erdem
dc.contributor.authorYang, Huan
dc.contributor.authorHiggs, Stephen
dc.contributor.authorChristadoss, Prernkumar
dc.contributor.authorSaini, Shamsher S.
dc.date.accessioned2021-03-06T09:55:09Z
dc.date.available2021-03-06T09:55:09Z
dc.identifier.citationTuzun E., Saini S. S. , Yang H., Alagappan D., Higgs S., Christadoss P., "Genetic evidence for the involvement of Fc gamma receptor III in experimental autoimmune myasthenia gravis pathogenesis", JOURNAL OF NEUROIMMUNOLOGY, cilt.174, ss.157-167, 2006
dc.identifier.issn0165-5728
dc.identifier.othervv_1032021
dc.identifier.otherav_e7cd5139-510a-4a76-bded-bb7439cba806
dc.identifier.urihttp://hdl.handle.net/20.500.12627/152394
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2006.01.015
dc.description.abstractImmune complexes and classical complement pathway play vital roles in experimental autoimmune myasthenia gravis (EAMG). To analyze the role of immune complex receptors in EAMG, Fc gamma RIII knockout (KO) mice were immunized with AChR and were found out to be resistant to EAMG induction. This was associated with reduced neuromuscular junction deposits, lymph node cell (LNC) IL-6 production and serum complement levels. EAMG resistance of anti-Clq Ab-administered mice was also associated with reduced LNC IL-6 production and neuromuscular junction deposits, indicating Clq involvement in EAMG resistance. The data provide the first direct genetic evidence for Fc gamma receptor involvement in EAMG pathogenesis. (c) 2006 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.titleGenetic evidence for the involvement of Fc gamma receptor III in experimental autoimmune myasthenia gravis pathogenesis
dc.typeMakale
dc.relation.journalJOURNAL OF NEUROIMMUNOLOGY
dc.contributor.department, ,
dc.identifier.volume174
dc.identifier.startpage157
dc.identifier.endpage167
dc.contributor.firstauthorID2383


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