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dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorArikoglu, Hilal
dc.contributor.authorGonen, MUSTAFA SAİT
dc.contributor.authorArslan, Ahmet
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorIpekci, Süleyman Hilmi
dc.contributor.authorKaya, Dudu Erkoc
dc.contributor.authorOzdemir, Hulya
dc.date.accessioned2021-03-06T09:56:37Z
dc.date.available2021-03-06T09:56:37Z
dc.date.issued2012
dc.identifier.citationGonen M. S. , Arikoglu H., Kaya D. E. , Ozdemir H., Ipekci S. H. , Arslan A., Kayis S. A. , Gogebakan B., "Effects of Single Nucleotide Polymorphisms in K-ATP Channel Genes on Type 2 Diabetes in a Turkish Population", ARCHIVES OF MEDICAL RESEARCH, cilt.43, ss.317-323, 2012
dc.identifier.issn0188-4409
dc.identifier.othervv_1032021
dc.identifier.otherav_e7f00047-a797-4a3e-8ed6-a920a728969a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/152482
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2012.06.001
dc.description.abstractBackground and Aims. ATP-sensitive potassium (K-ATP) channels of pancreatic beta-cells play a key role in glucose-stimulated insulin secretion mechanism. The Kir6.2 protein, forming the K-ATP channel pore inwardly, and the SUR1 protein that surrounds it forming the outside part of the channel were encoded by ABCC8 and KCNJ11 genes, respectively. Recent studies reported that the single nucleotide polymorphisms (SNPs) established in these genes are associated with defects in insulin secretion and type 2 diabetes mellitus (T2DM). We aimed to investigate the allele profiles and the risk alleles of the ABCC8 and KCNJ11 genes and to highlight the associations with the disease in patients in Konya region of Turkey where T2DM is common.
dc.language.isoeng
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectSağlık Bilimleri
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.titleEffects of Single Nucleotide Polymorphisms in K-ATP Channel Genes on Type 2 Diabetes in a Turkish Population
dc.typeMakale
dc.relation.journalARCHIVES OF MEDICAL RESEARCH
dc.contributor.departmentSelçuk Üniversitesi , ,
dc.identifier.volume43
dc.identifier.issue4
dc.identifier.startpage317
dc.identifier.endpage323
dc.contributor.firstauthorID104261


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