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dc.contributor.authorAydogmus, Zeynep
dc.contributor.authorInanli, Ipek
dc.date.accessioned2021-03-06T10:13:15Z
dc.date.available2021-03-06T10:13:15Z
dc.date.issued2007
dc.identifier.citationAydogmus Z., Inanli I., "Extractive spectrophotometric methods for determination of zolmitriptan in tablets", JOURNAL OF AOAC INTERNATIONAL, cilt.90, ss.1237-1241, 2007
dc.identifier.issn1060-3271
dc.identifier.othervv_1032021
dc.identifier.otherav_e955285c-a976-4cd7-beb9-847f06739be5
dc.identifier.urihttp://hdl.handle.net/20.500.12627/153307
dc.description.abstractTwo simple and sensitive extractive spectrophotometric methods have been developed for determination of zolmitriptan (ZTP) in tablets. These, methods are based on the formation of yellow ion-pair complexes between ZTP and tropaeolin 00 (TPOO) and bromothymol blue (BTB) in citrate-phosphate buffer of pH 4.0 and 6.0, respectively. The formed complexes were extracted with dichloromethane and measured at 411.5 and 410 nm for TPOO and BTB, respectively. The best conditions of the reactions were studied and optimized. Beer's law was obeyed in the concentration ranges of 2-20 and 1.5-17 mu g/mL with molar absorptivities of 1.42 x 10(4) and 1.60 x 10(4) L/mol/cm for the TPOO and BTB methods, respectively. Correlation coefficients were 0.9998 and 0.9999 for TPOO and BTB methods, respectively. Limits of detection of the TPOO and BTB methods were 0.341 and 0.344 mu g/mL, respectively, and the limits of quantitation were 1.034 and 1.051 mu g/mL, respectively. Sandell's sensitivity and stability constant were also calculated. The proposed methods have been applied successfully for the analysis of the drug in its dosage forms. No interference was observed from excipients present in tablets. Statistical comparison of the results with those obtained by a high-performance liquid chromatography method showed excellent agreement and indicated no significant differences in accuracy and precision.
dc.language.isoeng
dc.subjectZiraat
dc.subjectGıda Mühendisliği
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTarımsal Bilimler
dc.subjectTarım Bilimleri
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, ANALİTİK
dc.titleExtractive spectrophotometric methods for determination of zolmitriptan in tablets
dc.typeMakale
dc.relation.journalJOURNAL OF AOAC INTERNATIONAL
dc.contributor.department, ,
dc.identifier.volume90
dc.identifier.issue5
dc.identifier.startpage1237
dc.identifier.endpage1241
dc.contributor.firstauthorID184209


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