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dc.contributor.authorEroglu, L
dc.contributor.authorCaglayan, B
dc.contributor.authorTuna, R
dc.date.accessioned2021-03-06T10:23:10Z
dc.date.available2021-03-06T10:23:10Z
dc.date.issued1996
dc.identifier.citationEroglu L., Tuna R., Caglayan B., "Effects of nifedipine and Bay K 8644 on the R-PIA and caffeine-induced changes in the locomotor activity of rats", PHARMACOLOGICAL RESEARCH, cilt.33, ss.141-144, 1996
dc.identifier.issn1043-6618
dc.identifier.otherav_ea16af99-e6c9-440d-9410-fb9c8710a694
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/153772
dc.identifier.urihttps://doi.org/10.1006/phrs.1996.0021
dc.description.abstractPossible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated, R-PIA (0.05 mg kg(-1)), an adenosine analogue, (20 mg kg(-1)), an adenosine receptor antagonist, significantly decreased locomotor activity, respectively. Ca2+ channel blocker nifedipine (5 mg kg(-1)) and the channel activator Bay K 8644 (0.5 mg kg(-1)) did not alter the locomotor activity. However, both drugs significantly potentiated the inhibitory effect of R-PIA on the locomotor activity. Additionally, caffeine induced increase in the locomotor activity was significantly blocked by nifedipine and Bay K 8644, This interaction might be due to the inhibitory effects of nifedipine and Bay K 8644 on the uptake of adenosine by rat brain. (C) 1996 The Italian Pharmacological Society
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Bilimler
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleEffects of nifedipine and Bay K 8644 on the R-PIA and caffeine-induced changes in the locomotor activity of rats
dc.typeMakale
dc.relation.journalPHARMACOLOGICAL RESEARCH
dc.contributor.department, ,
dc.identifier.volume33
dc.identifier.issue2
dc.identifier.startpage141
dc.identifier.endpage144
dc.contributor.firstauthorID117229


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