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dc.contributor.authorOZBEK, UĞUR
dc.contributor.authorAydin, Müge
dc.contributor.authorHatirnaz, O
dc.contributor.authorERENSOY, Neslihan
dc.date.accessioned2021-03-06T10:49:40Z
dc.date.available2021-03-06T10:49:40Z
dc.date.issued2005
dc.identifier.citationAydin M., Hatirnaz O., ERENSOY N., OZBEK U., "CYP2D6 and CYP1A1 mutations in the Turkish population", CELL BIOCHEMISTRY AND FUNCTION, cilt.23, ss.133-135, 2005
dc.identifier.issn0263-6484
dc.identifier.othervv_1032021
dc.identifier.otherav_ec36ee76-b250-4d77-81cb-9b652c4dc738
dc.identifier.urihttp://hdl.handle.net/20.500.12627/155097
dc.identifier.urihttps://doi.org/10.1002/cbf.1222
dc.description.abstractDrugs and carcinogens are substrates of a group of metabolic enzymes including cytochrome p450 enzymes and gluthatione S-transferases. Many of the genes encoding these enzymes exhibit functional polymorphisms that contribute individual cancer susceptibility and drug response. Molecular studies based on these polymorphic enzymes also explain the aetiology of cancer and therapeutic management in clinics. We analysed the cytochrome p4501A1 (CYP1A1) and 2D6 (CYP2D6) variant genotype and allele frequencies by PCR-RFLP in Turkish individuals (n = 140). The frequency of the CYP1A1*2A mutant allele was found to be 15.4%, and the CYP2D6*3 and *4 mutant allele (poor metabolizer) frequencies were 2.5% and 13.9%, respectively. This study presents the first results of CYP1A1 and CYP2D6 mutant allele distributions in the Turkish population and these data provide an understanding of epidemiological studies that correlate therapeutic approaches and aetiology of several types of malignancy in Turkish patients. Copyright (C) 2005 John Wiley Sons, Ltd.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectHÜCRE BİYOLOJİSİ
dc.titleCYP2D6 and CYP1A1 mutations in the Turkish population
dc.typeMakale
dc.relation.journalCELL BIOCHEMISTRY AND FUNCTION
dc.contributor.departmentİstanbul Üniversitesi , Deneysel Tıp Araştırma Enstitüsü , Genetik
dc.identifier.volume23
dc.identifier.issue2
dc.identifier.startpage133
dc.identifier.endpage135
dc.contributor.firstauthorID417


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