Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis
Date
2007Author
Mülazımoğlu, Lutfiye
Şensoy, Demet
Kan, Pei Lee
Cevher, Erdal
Sağırlı, Olcay
Orhan, Zafer
Ahıskalı, Rengin
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Purpose: The aim of this study was to prepare poly(D, L- lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate ( SF) using a double emulsion solvent evaporation method with varying polymer: drug ratios (1: 1, 2.5: 1, 5: 1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis.
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