dc.contributor.author | Uzun, Hafize | |
dc.contributor.author | Teksoz, Serkan | |
dc.contributor.author | Goksoy, Ertuğrul | |
dc.contributor.author | Seymen, Hakki Oktay | |
dc.contributor.author | Saygili, Seha | |
dc.contributor.author | Yavuz, Nihat | |
dc.contributor.author | SÖZER, Volkan | |
dc.contributor.author | Goksel, Suha | |
dc.contributor.author | Tortum, Osman Baran | |
dc.contributor.author | Aytac, Erman | |
dc.date.accessioned | 2021-03-06T11:17:26Z | |
dc.date.available | 2021-03-06T11:17:26Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Aytac E., Teksoz S., Saygili S., Tortum O. B. , Yavuz N., SÖZER V., Goksel S., Uzun H., Seymen H. O. , Goksoy E., "Iloprost reduces colitis induced oxidative stress: An experimental study in rats", TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.24, ss.224-229, 2013 | |
dc.identifier.issn | 1300-4948 | |
dc.identifier.other | av_ee500cb1-5868-4f0f-a693-acb76c7d2ce6 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/156443 | |
dc.identifier.uri | https://doi.org/10.4318/tjg.2013.0491 | |
dc.description.abstract | Background/aims: Reactive oxygen. species have a known potent role in the pathogenesis of ulcerative colitis. Roprost, a pharmaceutical, is a chemically stable derivative of a naturally- occurring human prostacyclin. Several studies have demonstrated protective effects of iloprost via its antioxidant and its anti-inflammatory activity. The aim of this study is to evaluate the effects of iloprost on oxidant/antioxidant status, as well as the large bowel histopathology in experimental colitis. Materials and Method: Forty adult male Wistar-albino rats were randomly divided in to four equal weight-matched groups: sham group (n=10), iloprost administered sham group (n=10), colitis group (n=10), iloprost administered colitis group (n=10). Acetic acid (1 ml of 4% solution) was used to induce colonic inflammation in the rats. Results: Colonic tissue and plasma malondialdehyde levels were significantly lower in the iloprost administered colitis group than the colitis group (p<0.01). Tissue glutathione levels of the iloprost administered colitis group were significantly higher than the colitis group (p<0.001). Conclusion: We have demonstrated in this study iloprost to be an antioxidant, as well as iloprost demonstrating protective activity against colitis induced oxidative stress. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Gastroenteroloji-(Hepatoloji) | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | GASTROENTEROLOJİ VE HEPATOLOJİ | |
dc.title | Iloprost reduces colitis induced oxidative stress: An experimental study in rats | |
dc.type | Makale | |
dc.relation.journal | TURKISH JOURNAL OF GASTROENTEROLOGY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 24 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 224 | |
dc.identifier.endpage | 229 | |
dc.contributor.firstauthorID | 2749 | |