dc.contributor.author | Bakar, S | |
dc.contributor.author | Uyar, Fatma Aytül | |
dc.contributor.author | Eraksoy, M | |
dc.contributor.author | Saruhan-Direskeneli, G | |
dc.date.accessioned | 2021-03-06T11:39:23Z | |
dc.date.available | 2021-03-06T11:39:23Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Saruhan-Direskeneli G., Uyar F. A. , Bakar S., Eraksoy M., "Molecular analysis of HLA-DRB1, -DQA1 and -DQB1 polymorphism in Turkey.", Tissue antigens, cilt.55, ss.171-4, 2000 | |
dc.identifier.issn | 0001-2815 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_f013bf14-69e9-4797-b5cd-cc64d5e4e492 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/157567 | |
dc.identifier.uri | https://doi.org/10.1034/j.1399-0039.2000.550211.x | |
dc.description.abstract | We report the evaluation of MHC class II polymorphism in the population of Turkey. HLA-DRB1, -DQA1 and -DQB1 have been investigated by polymerase chain reaction and sequence-specific oligonucleotide probe hybridisations (PCR/SSO) and sequence-specific priming (SSP) in 250 randomly selected healthy individuals, We also report the allelic distribution of these genes. The most frequent alleles detected were DRB1*1101 (0.104), *0301 (0.092), *0701 (0.090), DQA1*0501 (0.334, *0102 (0.164) and *03 (0.148) and DQB1*0301 (0.256), *02 (0.164), *0302 (0.128). The frequent 'putative' three-locus haplotypes carry the most frequent alleles at these loci. The most frequently detected class II "haplotypes" are DRB1*1101 DQA1*0501 DQB1*0301 (0.100), DRB1*0301 DQA1*0501 DQB1*02 (0.092) and DRB1*0701 DQA1*0201 DQB1*02 (0.072). The distribution of alleles and 'putative' haplotypes has shown common features with other Mediterranean populations. The results extend the HLA map to another Mediterranean country and provide a database for further HLA-disease association studies and transplantation applications. | |
dc.language.iso | eng | |
dc.subject | PATOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Histoloji-Embriyoloji | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Patoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Temel Bilimler | |
dc.subject | İmmünoloji | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | HÜCRE BİYOLOJİSİ | |
dc.title | Molecular analysis of HLA-DRB1, -DQA1 and -DQB1 polymorphism in Turkey. | |
dc.type | Makale | |
dc.relation.journal | Tissue antigens | |
dc.contributor.department | , , | |
dc.identifier.volume | 55 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 171 | |
dc.identifier.endpage | 4 | |
dc.contributor.firstauthorID | 125068 | |