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dc.contributor.authorAlpertunga, Buket
dc.contributor.authorArda-Pirincci, Pelin
dc.contributor.authorBolkent, Sehnaz
dc.contributor.authorOzden, Sibel
dc.contributor.authorGezginci-Oktayoglu, Selda
dc.contributor.authorCatalgol, Betul
dc.date.accessioned2021-03-06T12:04:28Z
dc.date.available2021-03-06T12:04:28Z
dc.date.issued2009
dc.identifier.citationOzden S., Catalgol B., Gezginci-Oktayoglu S., Arda-Pirincci P., Bolkent S., Alpertunga B., "Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats", FOOD AND CHEMICAL TOXICOLOGY, cilt.47, ss.1676-1684, 2009
dc.identifier.issn0278-6915
dc.identifier.otherav_f21ae17a-40bb-4dd2-9a4f-b9c91cd5287b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/158819
dc.identifier.urihttps://doi.org/10.1016/j.fct.2009.04.018
dc.description.abstractMethiocarb, is used worldwide in agriculture and health programs. Besides its advantages in the agriculture, it causes several toxic effects. In this study, we aimed to investigate subacute effects of methiocarb on lipid peroxidation, reduced glutathione (GSH), antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) and histopathological changes in rat tissues. Moreover, we examined the possible protective effects of vitamin E and taurine on methiocarb-induced oxidative damage in rat tissues. Rats were randomly divided into six groups as follows; I-control group; II-methiocarb group; III-vitamin E group; IV-vitamin E + methiocarb group; V-taurine group and VI-taurine + methiocarb group. Methiocarb significantly increased lipid peroxidation in liver and kidney when compared to control groups. Levels of GSH and activities of SOD, CAT and GSH-Px were found to be decreased, while GSH-Rd remained unchanged in rat liver and kidney treated with methiocarb. Pretreatment of vitamin E and taurine resulted in a significant decrease on lipid peroxidation, alleviating effects on GSH and antioxidant enzymes. The degenerative histological changes were less in liver than kidney of rats treated with methiocarb. Pretreatment of vitamin E and taurine showed a protective effect on the histological changes in kidney comparing to the liver of rats treated with methiocarb. (C) 2009 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectGıda Mühendisliği
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.titleMethiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats
dc.typeMakale
dc.relation.journalFOOD AND CHEMICAL TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume47
dc.identifier.issue7
dc.identifier.startpage1676
dc.identifier.endpage1684
dc.contributor.firstauthorID14665


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