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dc.contributor.authorOlgac, Vakur
dc.contributor.authorKazancioglu, Hakki Oguz
dc.contributor.authorRUBACI, Asli Hayirlioglu
dc.contributor.authorAk, Gülsüm
dc.date.accessioned2021-03-06T12:06:43Z
dc.date.available2021-03-06T12:06:43Z
dc.date.issued2012
dc.identifier.citationRUBACI A. H. , Kazancioglu H. O. , Olgac V., Ak G., "The roles of matrix metalloproteinases-2,-7,-10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus", JOURNAL OF ORAL PATHOLOGY & MEDICINE, cilt.41, ss.689-696, 2012
dc.identifier.issn0904-2512
dc.identifier.othervv_1032021
dc.identifier.otherav_f253055c-0754-4761-8f72-3b84e3369fcd
dc.identifier.urihttp://hdl.handle.net/20.500.12627/158951
dc.identifier.urihttps://doi.org/10.1111/j.1600-0714.2012.01160.x
dc.description.abstractJ Oral Pathol Med (2012) 41: 689696 Background: The aim of this study was to investigate the roles of Matrix Metalloproteinases (MMP)-2, Metalloproteinases-7, Metalloproteinases-10 and Tissue Inhibitors of Metalloproteinase-1 (TIMP-1) in the pathogenesis of oral lichen planus (OLP) disease in same tissue samples. Methods: Thirty-nine individuals [29 patients with OLP (74%) and 10 healthy control subjects (25%)] were included in our study. The mean age was 48 +/- 14.39 with a range of 2075. Results: MMP-2 and MMP-7 expression was significantly different in the patient and control groups in the epithelium and the connective tissue (P < 0. 05). The ratio of MMP-2/TIMP-1 and MMP-7/TIMP-1 were higher in patient with OLP group than control group. Conclusions: Along with the exposure of the role of MMPs activity on diseases characterized by the tissue destruction, several studies were conducted on the pharmacological control of MMPs activity. However, understanding of the biological functions of MMPs is very important for the development and implementation of MMP inhibitors in the treatment of diseases. According to the results of this study, we suggest that MMP-2, MMP-7, and TIMP-1 may be involved in the formation of OLP lesions. Further studies on MMPs may be useful for understanding and treating the diseases such as OLP.
dc.language.isoeng
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectDiş Hekimliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectBiyoloji ve Biyokimya
dc.subjectPATOLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.titleThe roles of matrix metalloproteinases-2,-7,-10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus
dc.typeMakale
dc.relation.journalJOURNAL OF ORAL PATHOLOGY & MEDICINE
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume41
dc.identifier.issue9
dc.identifier.startpage689
dc.identifier.endpage696
dc.contributor.firstauthorID49089


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