Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock
Author
Ince, Can
Kapucu, Ayşegül
Guerci, Philippe
Ergin, Bulent
Hilty, Matthias P.
Jubin, Ronald
Bakker, Jan
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Background: Primary resuscitation fluid to treat hemorrhagic shock remains controversial. Use of hydroxyethyl starches raised concerns of acute kidney injury. Polyethylene-glycolated carboxyhemoglobin, which has carbon monoxide-releasing molecules and oxygen-carrying properties, was hypothesized to sustain cortical renal microcirculatory Po-2 after hemorrhagic shock and reduce kidney injury.
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