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dc.contributor.authorJung, Tobias
dc.contributor.authorGrune, Tilman
dc.contributor.authorCatalgol, Betuel
dc.date.accessioned2021-03-06T12:56:47Z
dc.date.available2021-03-06T12:56:47Z
dc.date.issued2009
dc.identifier.citationJung T., Catalgol B., Grune T., "The proteasomal system", MOLECULAR ASPECTS OF MEDICINE, cilt.30, ss.191-296, 2009
dc.identifier.issn0098-2997
dc.identifier.otherav_f6572539-f0c8-47ae-a415-108d40f651be
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/161388
dc.identifier.urihttps://doi.org/10.1016/j.mam.2009.04.001
dc.description.abstractRising interest in the mechanism and function of the proteasomes and the ubiquitin system revealed that it is hard to find any aspect of the cellular metabolic network that is not directly or indirectly affected by the degradation system. This includes the cell cycle, the "quality control" of newly synthesized proteins (ERAD), transcription factor regulation, gene expression, cell differentiation, immune response or pathologic processes like cancer, neurodegenerative diseases, lipofuscin formation, diabetes, atherosclerosis, inflammatory processes or cataract formation and in addition to that the aging process itself and the degradation of oxidized proteins, in order to maintain cell homeostasis. But also this seems to be only a small aspect of the general view. The various regulator proteins that are able to change the rate or specificity of proteolysis, fitting it out for highly specialized tasks, or the precise regulation of the half-life of cellular proteins by ubiquitin-mediated degradation shape the proteasome and the ubiquitin-proteasome system into a fascinating and essential part of cellular function in the three kingdoms of bacteria, plants and animals.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleThe proteasomal system
dc.typeMakale
dc.relation.journalMOLECULAR ASPECTS OF MEDICINE
dc.contributor.departmentUniversity Hohenheim , ,
dc.identifier.volume30
dc.identifier.issue4
dc.identifier.startpage191
dc.identifier.endpage296
dc.contributor.firstauthorID192926


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