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Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats

dc.contributor.authorUysal, M
dc.contributor.authorSeckin, S
dc.contributor.authorAykac-Toker, G
dc.contributor.authorBastar, I
dc.date.accessioned2021-03-06T13:06:30Z
dc.date.available2021-03-06T13:06:30Z
dc.date.issued1998
dc.identifier.citationBastar I., Seckin S., Uysal M., Aykac-Toker G., "Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats", RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, cilt.102, ss.265-272, 1998
dc.identifier.issn1078-0297
dc.identifier.othervv_1032021
dc.identifier.otherav_f70da085-6d02-4d11-a5a3-9c190123acb7
dc.identifier.urihttp://hdl.handle.net/20.500.12627/161865
dc.description.abstractIn this study, the effect of streptozotocin (STZ) on lipid peroxidation and glutathione (GSH) content was investigated in the liver, pancreas and kidney of rats. Lipid peroxide levels were significantly increased in homogenates and mitochondrial fractions of the liver, kidney acid pancreas after STZ administration. GSH levels in hepatic acid pancreatic tissues were decreased but unchanged in the kidney of diabetic rats. GSH content in hepatic mitochondrial fraction was also decreased compared to control group. On the other hand, the destruction of pancreatic beta-cells was also observed histopathologically. Our results indicate that oxidative stress may play an important role in STZ induced diabetes and mitochondrial fraction may be the target in this toxicity.
dc.language.isoeng
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleEffect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats
dc.typeMakale
dc.relation.journalRESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
dc.contributor.department, ,
dc.identifier.volume102
dc.identifier.issue3
dc.identifier.startpage265
dc.identifier.endpage272
dc.contributor.firstauthorID121785


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