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SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus

dc.contributor.authorHacioglu, Y.
dc.contributor.authorMutlu, T.
dc.contributor.authorNiyazioglu, M.
dc.contributor.authorTuncdemir, M.
dc.contributor.authorGuven, M.
dc.contributor.authorDincer, Y.
dc.contributor.authorCaliskan, Z.
dc.date.accessioned2021-03-06T13:07:04Z
dc.date.available2021-03-06T13:07:04Z
dc.identifier.citationCaliskan Z., Mutlu T., Guven M., Tuncdemir M., Niyazioglu M., Hacioglu Y., Dincer Y., "SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus", GENE, cilt.642, ss.542-548, 2018
dc.identifier.issn0378-1119
dc.identifier.othervv_1032021
dc.identifier.otherav_f71b419b-ec68-4620-b7f9-10bbd24a9415
dc.identifier.urihttp://hdl.handle.net/20.500.12627/161898
dc.identifier.urihttps://doi.org/10.1016/j.gene.2017.11.071
dc.description.abstractSirtuins (SIRTs) is a family of NAD+ dependent histone deacetylases. SIRT6 takes play in glucose homeostasis, genomic stability and DNA repair. Although increased oxidative DNA damage and decreased DNA repair activity were determined in diabetes mellitus, the possible relation between level of oxidative DNA damage and SIRT6 expression has not been investigated so far. We determined SIRT6 expression and urinary 8-hydroxy deoxyguanosine (8-OHdG) levels, marker of oxidative DNA damage, in cases with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM).
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectGENETİK VE HAYAT
dc.titleSIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus
dc.typeMakale
dc.relation.journalGENE
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume642
dc.identifier.startpage542
dc.identifier.endpage548
dc.contributor.firstauthorID251313


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