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dc.contributor.authorGuclu, Kubilay
dc.contributor.authorElhussein, Elaf Abdelillah Ali
dc.contributor.authorOzyurek, Mustafa
dc.contributor.authorSahin, Selin
dc.contributor.authorBilgin, Mehmet
dc.date.accessioned2021-03-06T13:07:57Z
dc.date.available2021-03-06T13:07:57Z
dc.identifier.citationBilgin M., Elhussein E. A. A. , Ozyurek M., Guclu K., Sahin S., "Optimizing the extraction of polyphenols from Sideritis montana L. using response surface methodology", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.158, ss.137-143, 2018
dc.identifier.issn0731-7085
dc.identifier.othervv_1032021
dc.identifier.otherav_f730b73b-117a-422d-9806-bdca00e729bf
dc.identifier.urihttp://hdl.handle.net/20.500.12627/161951
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2018.05.039
dc.description.abstractSideritis montana L. endemic of Turkey was screened for its polyphenols content and antioxidant activity. Factor analysis and experimental design have been applied to understand the structure of the separation process, to determine the effective parameters, and to accomplish the performance improvement. Face-centred composite design (FCD) of response surface methodology (RSM) was applied to evaluate the influences of solvent concentration, solvent amount, extraction time, and stirring speed of homogenizer-assisted extraction (HAE) as well as to model and to optimize the HAE. Quadratic models were highly significant (p < 0.0001) for the responses studied with high coefficients of determination (R-2) of 0.9440, 0.9415 and 0.9521. The result of the study suggests that 15.02 mL of 22.69% EtOH solution (v/v), 70.16 s, and 9524.52 rpm of mixing speed are the optimal conditions to obtain the highest yield of total polyphenols (TPC) and flavonoids (TFC), and the best antioxidant activity (AA). Rosmarinic acid was identified as the most abundant component. (C) 2018 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, ANALİTİK
dc.titleOptimizing the extraction of polyphenols from Sideritis montana L. using response surface methodology
dc.typeMakale
dc.relation.journalJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
dc.contributor.departmentIstanbul University - Cerrahpasa , ,
dc.identifier.volume158
dc.identifier.startpage137
dc.identifier.endpage143
dc.contributor.firstauthorID651088


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