Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations

Date
2001
Author
Gul, A
Inanc, Murat
Ordi, J
Bruce, I
Hajeer, A
El-Magadmi, M
Alansari, A
Teh, LS
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Abstract
Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C. which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations.
URI
http://hdl.handle.net/20.500.12627/162095
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