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dc.contributor.authorEngin, Burhan
dc.contributor.authorCelik, Ugur
dc.contributor.authorSerdaroglu, Server
dc.contributor.authorKutlubay, Zekayi
dc.contributor.authorTuzun, Yalçın
dc.date.accessioned2021-03-02T23:01:47Z
dc.date.available2021-03-02T23:01:47Z
dc.date.issued2015
dc.identifier.citationEngin B., Kutlubay Z., Celik U., Serdaroglu S., Tuzun Y., "Hailey-Hailey disease: A fold (intertriginous) dermatosis", CLINICS IN DERMATOLOGY, cilt.33, sa.4, ss.452-455, 2015
dc.identifier.issn0738-081X
dc.identifier.otherav_10068fdf-91dd-4d80-ba7a-e69a76c2b846
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16300
dc.identifier.urihttps://doi.org/10.1016/j.clindermatol.2015.04.006
dc.description.abstractHailey-Hailey disease, also called benign familial pemphigus, is a late-onset blistering disorder that affects the flexures. There are typically painful erosions and cracks in affected areas. Lesions generally begin between 20 and 40 years of age. In two third of all cases, positive family history is detected. In pathogenesis, there is a defect in keratinocyte adhesion due to ATP2 C1 gene mutation. The result of the desmosomal decomposition is acantholysis. Menstruation, pregnancy, skin infections, physical trauma, excessive sweating and exposure to ultraviolet radiation are important triggering factors. Histopathologic changes are suprabasal acantholysis and formation of intraepidermal bullae. In the epidermis, a partial acantholysis that looks like broken bricks is observed. (C) 2015 Elsevier Inc. All rights reserved.
dc.language.isoeng
dc.subjectDermatoloji
dc.subjectDERMATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.titleHailey-Hailey disease: A fold (intertriginous) dermatosis
dc.typeMakale
dc.relation.journalCLINICS IN DERMATOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume33
dc.identifier.issue4
dc.identifier.startpage452
dc.identifier.endpage455
dc.contributor.firstauthorID3388


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