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dc.contributor.authorDemir, Kamber
dc.contributor.authorBACINOĞLU, Süleyman
dc.contributor.authorOzsoy, Yildiz
dc.contributor.authorPabuccuoglu, Serhat
dc.contributor.authorCevher, Erdal
dc.contributor.authorCirit, Umut
dc.contributor.authorGok, Mehmet Koray
dc.contributor.authorOzgumus, Saadet
dc.date.accessioned2021-03-06T20:11:49Z
dc.date.available2021-03-06T20:11:49Z
dc.identifier.citationGok M. K. , Ozgumus S., Demir K., Cirit U., Pabuccuoglu S., Cevher E., Ozsoy Y., BACINOĞLU S., "Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine", CARBOHYDRATE POLYMERS, cilt.136, ss.63-70, 2016
dc.identifier.issn0144-8617
dc.identifier.othervv_1032021
dc.identifier.otherav_f9300574-1eb5-4217-9080-84bb722035a5
dc.identifier.urihttp://hdl.handle.net/20.500.12627/163219
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2015.08.079
dc.description.abstractThe aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly( acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)(gc) indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine. (C) 2015 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, UYGULAMALI
dc.titleDevelopment of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine
dc.typeMakale
dc.relation.journalCARBOHYDRATE POLYMERS
dc.contributor.departmentDicle Üniversitesi , ,
dc.identifier.volume136
dc.identifier.startpage63
dc.identifier.endpage70
dc.contributor.firstauthorID10217


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