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dc.contributor.authorAltug, T
dc.contributor.authorCakatay, U
dc.contributor.authorKayali, R
dc.contributor.authorAkcay, T
dc.date.accessioned2021-03-06T20:30:41Z
dc.date.available2021-03-06T20:30:41Z
dc.date.issued2006
dc.identifier.citationKayali R., Cakatay U., Akcay T., Altug T., "Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat", CELL BIOCHEMISTRY AND FUNCTION, cilt.24, ss.79-85, 2006
dc.identifier.issn0263-6484
dc.identifier.otherav_fa7f56a7-045a-4d50-8b0a-090e1f405d00
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/164026
dc.identifier.urihttps://doi.org/10.1002/cbf.1190
dc.description.abstractIn the present study, we investigated whether DL-alpha-lipoic acid (LA) supplementation could have prooxidant or antioxidant effects on oxidative protein damage parameters such as protein carbonyl (PCO), nitrotyrosine (NT), advanced oxidation protein products (AOPP), and protein thiol (P-SH), as well as oxidative stress parameters such as total thiol (T-SH), nonprotein thiol (Np-SH), and lipid hydroperoxide (LHP) in the brain and the skeletal muscle tissue of aged rats. PCO, and NT levels were increased, AOPP and P-SH levels were not changed in the brain tissue of aged rats given LA supplementation. On the other hand, TSH, Np-SH, and LHP levels were decreased in the brain tissue of aged rats given LA supplementation. The levels of the same parameters were not significantly different in the skeletal muscle tissue of aged rats given LA supplementation. The increased levels of protein oxidation markers such as PCO, and NT in the brain tissue of LA-supplemenled aged rats compared with non-supplemented aged rats may suggest that oxidative protein damage is increased in LA-supplemented aged rats. We assume that an explanation for our findings regarding LA supplementation on protein oxidation markers in the brain tissue of aged rats may be due to the prooxidant effects of LA. Depending on post-mitotic tissue type and dosage of LA, the prooxidant effects of LA supplementation, should be considered in future studies. Copyright (c) 2004 John Wiley & Sons, Ltd.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleEffect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat
dc.typeMakale
dc.relation.journalCELL BIOCHEMISTRY AND FUNCTION
dc.contributor.department, ,
dc.identifier.volume24
dc.identifier.issue1
dc.identifier.startpage79
dc.identifier.endpage85
dc.contributor.firstauthorID177329


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