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dc.contributor.authorKaraaltin, M. V.
dc.contributor.authorKecik, A.
dc.contributor.authorOner, F.
dc.contributor.authorOzalp, B.
dc.contributor.authorKayikcioglu, A.
dc.contributor.authorDadaci, M.
dc.date.accessioned2021-03-06T20:41:14Z
dc.date.available2021-03-06T20:41:14Z
dc.date.issued2013
dc.identifier.citationKaraaltin M. V. , Ozalp B., Dadaci M., Kayikcioglu A., Kecik A., Oner F., "The effects of 5-fluorouracil on flexor tendon healing by using a biodegradable gelatin, slow releasing system: experimental study in a hen model", JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, cilt.38, ss.651-657, 2013
dc.identifier.issn1753-1934
dc.identifier.othervv_1032021
dc.identifier.otherav_fb477a86-14bc-4e16-a6d6-41c38b11aa34
dc.identifier.urihttp://hdl.handle.net/20.500.12627/164512
dc.identifier.urihttps://doi.org/10.1177/1753193412458646
dc.description.abstractThis study investigated the effects of 5-fluorouracil in a slow-release biodegradable gelatin system on tendon healing. Gelatin blocks prepared in a size of 10 x 20 x 1 mm were loaded with 10, 20, and 30 mg of 5-fluorouracil, and 30 adult white Leghorn chickens were used. The tendons to the third and fourth toes were severed and repaired. The extremities were casted for three weeks. After sacrifice, the tendons were examined histologically and biomechanically for adhesion formation. The 10 mg-loaded gelatin group showed a decrease in adhesion formation when compared with the operative control group; the 20 and 30 mg groups showed signs of severe inflammation. Low doses of 5-fluorouracil applied via a slow-release gelatin system reduced adhesion formation in flexor tendon healing.
dc.language.isoeng
dc.subjectOrtopedi ve Travmatoloji
dc.subjectORTOPEDİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectCERRAHİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.titleThe effects of 5-fluorouracil on flexor tendon healing by using a biodegradable gelatin, slow releasing system: experimental study in a hen model
dc.typeMakale
dc.relation.journalJOURNAL OF HAND SURGERY-EUROPEAN VOLUME
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , ,
dc.identifier.volume38
dc.identifier.issue6
dc.identifier.startpage651
dc.identifier.endpage657
dc.contributor.firstauthorID210016


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