Show simple item record

dc.contributor.authorKucuk, Mutlu
dc.contributor.authorKaya, Mehmet
dc.contributor.authorArican, Nadir
dc.contributor.authorGurses, Candan
dc.contributor.authorAhishali, Bulent
dc.contributor.authorYilmaz, Canan Ugur
dc.contributor.authorEMİK, Serkan
dc.contributor.authorOrhan, Nurcan
dc.contributor.authorTemizyurek, Arzu
dc.contributor.authorAtis, Muge
dc.contributor.authorAkcan, Ugur
dc.contributor.authorKhodadust, Rouhollah
dc.date.accessioned2021-03-06T20:43:47Z
dc.date.available2021-03-06T20:43:47Z
dc.identifier.citationYilmaz C. U. , EMİK S., Orhan N., Temizyurek A., Atis M., Akcan U., Khodadust R., Arican N., Kucuk M., Gurses C., et al., "Targeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats", LIFE SCIENCES, cilt.257, 2020
dc.identifier.issn0024-3205
dc.identifier.othervv_1032021
dc.identifier.otherav_fb7f52ed-e53e-4d02-be69-7a55174d3373
dc.identifier.urihttp://hdl.handle.net/20.500.12627/164652
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2020.118081
dc.description.abstractTemporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures, and currently available drugs may fail to provide a thorough treatment of the patients. The present study demonstrates the utility of glucose-coated gold nanoparticles (GNPs) as selective carriers of an antiepileptic drug, lacosamide (LCM), in developing a strategy to cross the blood-brain barrier to overcome drug resistance. Intravenous administration of LCM-loaded GNPs to epileptic animals yielded significantly higher nanoparticle levels in the hippocampus compared to the nanoparticle administration to intact animals. The amplitude and frequency of EEG-waves in both ictal and interictal stages decreased significantly after LCM-GNP administration to animals with TLE, while a decrease in the number of seizures was also observed though statistically insignificant. In these animals, malondialdehyde was unaffected, and glutathione levels were lower in the hippocampus compared to sham. Ultrastructurally, LCM-GNPs were observed in the brain parenchyma after intravenous injection to animals with TLE. We conclude that glucose-coated GNPs can be efficient in transferring effective doses of LCM into the brain enabling elimination of the need to administer high doses of the drug, and hence, may represent a new approach in the treatment of drug-resistant TLE.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.titleTargeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats
dc.typeMakale
dc.relation.journalLIFE SCIENCES
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume257
dc.contributor.firstauthorID2286324


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record