dc.contributor.author | KARA, Asuman | |
dc.contributor.author | Uzun, Hafize | |
dc.contributor.author | AKALIN, Esma Seda | |
dc.contributor.author | CAGLAR, Emel | |
dc.contributor.author | Onal, Burak | |
dc.contributor.author | KORUCU, Ercan | |
dc.contributor.author | Ozyigit, Leyla Pur | |
dc.contributor.author | ORTAKOYLU, Mediha Gonenc | |
dc.contributor.author | BAHADIR, Ayse | |
dc.date.accessioned | 2021-03-06T20:56:13Z | |
dc.date.available | 2021-03-06T20:56:13Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | KORUCU E., Ozyigit L. P. , ORTAKOYLU M. G. , BAHADIR A., AKALIN E. S. , KARA A., Uzun H., Onal B., CAGLAR E., "CATHELICIDIN AS A LINK BETWEEN SARCOIDOSIS AND TUBERCULOSIS", SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, cilt.32, ss.222-227, 2015 | |
dc.identifier.issn | 1124-0490 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_fc720825-33ac-4e7e-802a-7749f2635b63 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/165217 | |
dc.description.abstract | Setting: Sarcoidosis and tuberculosis share notable clinical, radiological, histological, and immunological similarities. The importance of vitamin D has long been investigated in these two granulomatous lung diseases. Cathelicidin is an antimicrobial peptide of the innate immune system, directly induced by vitD3. Objective: To evaluate the role of cathelicidin in sarcoidosis and tuberculosis development. Design: The study included 30 consecutive patients with active lung tuberculosis, 30 patients with sarcoidosis, and 20 healthy controls. 25-hydroxyvitamin D [25(OH) D] and cathelicidin levels were measured in blood samples. Results: Vitamin D levels were significantly higher (p<0.001) in tuberculosis patients (22.5 +/- 9.96 ng/ml) than in sarcoidosis patients (11.75 +/- 8.92 ng/ml). Severe vitamin D deficiency was as frequent as 47% in sarcoidosis patients compared to only 3% in tuberculosis patients. Cathelicidin levels were significantly higher in the control group (120.37 +/- 41.03 pg/ml) than in sarcoidosis (67.68 +/- 38.03 pg/ml) and tuberculosis (68.74 +/- 39.44 pg/ml) patients (p<0.001). However, no significant difference in cathelicidin levels was observed between tuberculosis and sarcoidosis patients (p=0.966). The optimum cathelicidin cut-off value to distinguish sarcoidosis patients from healthy controls was 107.14 pg/ml (sensitivity 81.5%, specificity 71.2%). Conclusion: Cathelicidin appears to play different roles in the development of granulomatous lung disease. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.title | CATHELICIDIN AS A LINK BETWEEN SARCOIDOSIS AND TUBERCULOSIS | |
dc.type | Makale | |
dc.relation.journal | SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES | |
dc.contributor.department | Istanbul Yedikule Chest Diseases & Thoracic Surgery Training & Research Hospital , , | |
dc.identifier.volume | 32 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 222 | |
dc.identifier.endpage | 227 | |
dc.contributor.firstauthorID | 19388 | |