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The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy

dc.contributor.authorMoshe, Solomon L.
dc.contributor.authorCarcak, Nihan
dc.contributor.authorEryigit, Tugba
dc.contributor.authorGalanopoulou, Aristea S.
dc.contributor.authorOnat, Filiz Yilmaz
dc.contributor.authorAkman, Ozlem
dc.contributor.authorGulcebi, Medine I.
dc.contributor.authorOzatman, Sema Ketenci
dc.date.accessioned2021-03-06T20:58:45Z
dc.date.available2021-03-06T20:58:45Z
dc.date.issued2015
dc.identifier.citationAkman O., Gulcebi M. I. , Carcak N., Ozatman S. K. , Eryigit T., Moshe S. L. , Galanopoulou A. S. , Onat F. Y. , "The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy", EPILEPSIA, cilt.56, ss.1793-1802, 2015
dc.identifier.issn0013-9580
dc.identifier.othervv_1032021
dc.identifier.otherav_fcb25fa5-461d-48b5-ad0a-af412f430af0
dc.identifier.urihttp://hdl.handle.net/20.500.12627/165359
dc.identifier.urihttps://doi.org/10.1111/epi.13204
dc.description.abstractObjectiveGenetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the propagation and modulation of seizures in kindling. We first examined the role of the SNRanterior and SNRposterior subregions in the resistance to the development of kindling in GAERS. Subsequently, to determine whether kindling resistance relates to differential sensitivity of -aminobutyric acid -aminobutyric acid (GABA)ergic or dopaminergic SNR neurons to kindling, we studied the effects of kindling-inducing stimulations on parvalbumin (PRV; GABAergic neuron marker) or tyrosine hydroxylase (TH; dopaminergic neuron marker) immunoreactivity (ir), respectively, in GAERS and in nonepileptic control (NEC) Wistar rats that lack kindling resistance.
dc.language.isoeng
dc.subjectNöroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleThe role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy
dc.typeMakale
dc.relation.journalEPILEPSIA
dc.contributor.departmentİstanbul Bilim Üniversitesi , ,
dc.identifier.volume56
dc.identifier.issue11
dc.identifier.startpage1793
dc.identifier.endpage1802
dc.contributor.firstauthorID82369


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