KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction
Tarih
2004Yazar
Riegger, GAJ
Erdmann, J
Holmer, S
Wollnik, B
Schunkert, H
Jeron, A
Hengstenberg, C
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Purpose. Patients with an acute myocardial infarction (AMI) are of high risk to develop ischemia-induced ventricular arrhythmias, leading to sudden cardiac death (SCD) in about one third of all AMI patients. The individual susceptibility to ischemia-induced arrhythmias may be modified by polymorphisms in genes encoding ion channels. The cardiac ATP-dependent potassium channel (K-ATP) current is generated by ion channels encoded by the KCNJ11 gene and the SUR2a gene. Opening of the K-ATP channel during ischemia results in action potential shortening in various studies and may therefore influence the outcome of AMI patients.
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