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dc.contributor.authorSavran, Fatma O.
dc.contributor.authorBayram, Aysel
dc.contributor.authorTurkmen, Aydin
dc.contributor.authorArikan, Evsen A.
dc.contributor.authorOzluk, Yasemin
dc.contributor.authorSever, Mehmet S.
dc.contributor.authorAkgul, Sebahat
dc.contributor.authorKilicaslan, Isin
dc.contributor.authorSevinc, Mustafa
dc.contributor.authorCaliskan, Yasar
dc.date.accessioned2021-03-02T23:06:57Z
dc.date.available2021-03-02T23:06:57Z
dc.date.issued2017
dc.identifier.citationOzluk Y., Caliskan Y., Sevinc M., Bayram A., Arikan E. A. , Turkmen A., Akgul S., Savran F. O. , Sever M. S. , Kilicaslan I., "Re-evaluation of glomerulitis using occlusion criteria based on the Banff 2013 revision: a retrospective study.", Transplant international : official journal of the European Society for Organ Transplantation, cilt.30, sa.6, ss.579-588, 2017
dc.identifier.issn0934-0874
dc.identifier.otherav_1096d082-8d39-4361-81a2-88649597eaa4
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16645
dc.identifier.urihttps://doi.org/10.1111/tri.12943
dc.description.abstractThe presence of occlusion/near-occlusion of glomerular capillaries was recently added to the existing definition of glomerulitis (g). We retrospectively re-evaluated 135 renal allograft biopsies regarding g to ensure no antibody-damaged grafts were missed. Previous and revised g scores (pg and rg, respectively) were compared for clinicopathologic correlations. The g score did not change in 100 (74.1%) biopsies. Thirty-five (25.9%) biopsies were changed to a lower score. Sensitivity and specificity of pg and rg for the presence of donor-specific antibodies (DSA) were 76% vs. 58% and 70% vs. 79%, respectively. Pg score indicated graft loss with 65% sensitivity and 63% specificity, whereas rg showed 46% sensitivity and 71% specificity. Area under the curve (AUC) values in ROC analysis for DSA and graft loss were as follows: pg, 0.773; rg, 0.693; and pg, 0.635; rg, 0.577, respectively. A comparison of the two AUC values revealed a significant difference between pg and rg only for DSA (P=0.0076). Pg and post-transplant time of biopsy independently predicted graft loss, whereas rg did not. In conclusion, revised g scores showed lesser sensitivity but higher specificity for DSA and graft loss. Recent definition of g missed antibody-mediated rejection in few cases, and it was not an independent predictor for graft loss.
dc.language.isoeng
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectTRANSPLANTASYON
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.titleRe-evaluation of glomerulitis using occlusion criteria based on the Banff 2013 revision: a retrospective study.
dc.typeMakale
dc.relation.journalTransplant international : official journal of the European Society for Organ Transplantation
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume30
dc.identifier.issue6
dc.identifier.startpage579
dc.identifier.endpage588
dc.contributor.firstauthorID72524


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