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dc.contributor.authorAydın, Şükriye Beste
dc.contributor.authorKeles, Uestuener O.
dc.date.accessioned2021-03-02T23:08:56Z
dc.date.available2021-03-02T23:08:56Z
dc.identifier.citationAydın Ş. B. , Keles U. O. , "EVALUATION OF FLUNIXIN MEGLUMINE GENOTOXICITY USING IN VITRO AND IN VIVO/IN VITRO MICRONUCLEUS TEST", ACTA VETERINARIA-BEOGRAD, cilt.59, ss.601-611, 2009
dc.identifier.issn0567-8315
dc.identifier.othervv_1032021
dc.identifier.otherav_10ba007d-3a0b-4e38-9775-7c4809a1be47
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16748
dc.identifier.urihttps://doi.org/10.2298/avb0906601a
dc.description.abstractThe aim of this study was to investigate the genotoxic effects of flunixin meglumine on mice peripheral lymphocytes by in vitro and in vivo/invitro cytokinesis block micronucleus tests (CBMN). Flunixin meglumine was used at concentrations of 25, 50 and 100 mu g/mL for the in vitro assay and 50, 75 and 100 mg/kg for the in vivo/in vitro assay. Mice were treated intraperitonally twice with a 24 h interval and sacrificed 6 h after the last dose. Cardiac blood was taken and added to the cultures for the in vivo/in vitro test. 21 h after the addition of the test compund for the in vitro test, and after the initiation of incubation for in vivo/in vitro test cytokinesis was blocked with the addition of cytochalasin-B and 20 h later the cultures were harvested. In both test systems, a negative and a positive control mitomycin C (MMC) were also included.
dc.language.isoeng
dc.subjectTarımsal Bilimler
dc.subjectVeteriner Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectVETERİNERLİK BİLİMLERİ
dc.titleEVALUATION OF FLUNIXIN MEGLUMINE GENOTOXICITY USING IN VITRO AND IN VIVO/IN VITRO MICRONUCLEUS TEST
dc.typeMakale
dc.relation.journalACTA VETERINARIA-BEOGRAD
dc.contributor.departmentİstanbul Teknik Üniversitesi , Maden , Cevher Hazırlama Mühendisliği
dc.identifier.volume59
dc.identifier.startpage601
dc.identifier.endpage611
dc.contributor.firstauthorID45440


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