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dc.contributor.authorÇAKIR, FATMA BETÜL
dc.contributor.authorKebudi, Rejin
dc.date.accessioned2021-03-02T23:09:02Z
dc.date.available2021-03-02T23:09:02Z
dc.date.issued2013
dc.identifier.citationKebudi R., ÇAKIR F. B. , "Management of Diffuse Pontine Gliomas in Children: Recent Developments", PEDIATRIC DRUGS, cilt.15, sa.5, ss.351-362, 2013
dc.identifier.issn1174-5878
dc.identifier.otherav_10bc2d80-30df-478e-af69-7cc7bb501f51
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16756
dc.identifier.urihttps://doi.org/10.1007/s40272-013-0033-5
dc.description.abstractThe prognosis for children with diffuse intrinsic pontine gliomas (DIPGs) is dismal. Although DIPGs constitute only 10-15 % of all pediatric brain tumors, they are the main cause of death in this group with a median survival of less than 12 months. Standard therapy involves radiotherapy, which produces transient neurologic improvement. Despite several clinical trials having been conducted, including trials on targeted agents to assess their efficacy, there is no clear improvement in prognosis. However, knowledge of DIPG biology is increasing, mainly as a result of research using biopsy and autopsy samples. In this review, we discuss recent studies in which systemic therapy was administered prior to, concomitantly with, or after radiotherapy. The discussion also includes novel therapeutic options in DIPG. Continuing multimodal and multitargeted therapies might lead to an improvement in the dismal prognosis of the disease.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectPEDİATRİ
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectEczacılık
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectTemel Bilimler
dc.titleManagement of Diffuse Pontine Gliomas in Children: Recent Developments
dc.typeMakale
dc.relation.journalPEDIATRIC DRUGS
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü
dc.identifier.volume15
dc.identifier.issue5
dc.identifier.startpage351
dc.identifier.endpage362
dc.contributor.firstauthorID23553


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