dc.contributor.author | Saglam, Zuhal A. | |
dc.contributor.author | KAZANCIOĞLU, Rümeyza | |
dc.contributor.author | Saler, Tayyibe | |
dc.contributor.author | Ecebay, Alphan | |
dc.contributor.author | Ozturk, Savaş | |
dc.contributor.author | Sar, Fuat | |
dc.date.accessioned | 2021-03-08T18:31:38Z | |
dc.date.available | 2021-03-08T18:31:38Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Sar F., Saler T., Ecebay A., Saglam Z. A. , Ozturk S., KAZANCIOĞLU R., "The efficacy of n-acetylcysteine in preventing contrast-induced nephropathy in type 2 diabetic patients without nephropathy", Journal of Nephrology, cilt.23, sa.4, ss.478-482, 2010 | |
dc.identifier.issn | 1121-8428 | |
dc.identifier.other | av_b5e765a8-6454-4796-887f-37d09ab77999 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/167708 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955436635&origin=inward | |
dc.description.abstract | Background: N-acetylcysteine (NAC) is reported to have potential for prevention of contrast-induced nephropathy(CIN), however, there is not enough data related to its effects on diabetic patients without nephropathy. Methods: A total of 45 diabetic patients without nephropathy undergoing a computerized tomography (CT) investigation and who would be receiving radio-opaque medication (300 mg iohexaol/100 mL) were enrolled. They were randomized to have either high-dose NAC (1200 mg) plus saline hydration (Group 1, n=25) or only saline hydration (Group 2; n=20). Serum creatinine levels were determined 72 hours post-contrast. CIN was defined as 0.3 mg/dL elevation of creatinine from baseline and/or an increment of 20% over baseline creatinine and/or 20% decrement of estimated GFR. Results: In Group 1, serum creatinine decreased from 0.83 to 0.79 mg/dL, whereas serum creatinine increased from 0.81 to 0.94mg/dL in Group 2 (not significant for both groups). However there was a significant difference between the creatinine variation of two groups (p=0.031). Furthermore, the groups were analyzed according to overall incidence of CIN. The increase of serum creatinine and decrement of estimated GFR in Group 2 were significantly higher than in Group 1. Conclusion: Adding NAC to saline hydration seems more beneficial than saline hydration alone in preventing contrast-induced renal function deterioration in type 2 diabetic patients without nephropathy. © 2010 Società Italiana di Nefrologia. | |
dc.language.iso | eng | |
dc.subject | Nephrology | |
dc.subject | Health Sciences | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Nefroloji | |
dc.subject | İç Hastalıkları | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | ÜROLOJİ VE NEFROLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.title | The efficacy of n-acetylcysteine in preventing contrast-induced nephropathy in type 2 diabetic patients without nephropathy | |
dc.type | Makale | |
dc.relation.journal | Journal of Nephrology | |
dc.contributor.department | , , | |
dc.identifier.volume | 23 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 478 | |
dc.identifier.endpage | 482 | |
dc.contributor.firstauthorID | 2529065 | |