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dc.contributor.authorKaradag, Remzi
dc.contributor.authorMansour, Ahmad M.
dc.contributor.authorBelfaiza, Soukaina
dc.contributor.authorGungor, Sirel Gur
dc.contributor.authorParodi, Maurizio Battaglia
dc.contributor.authorMansour, Hana A.
dc.contributor.authorOzdal, Pinar C.
dc.contributor.authorKADAYIFÇILAR, SİBEL
dc.contributor.authorTugal-Tutkun, Ilknur
dc.contributor.authorESER ÖZTÜRK, HİLAL
dc.contributor.authorYALÇINDAĞ, FATİME NİLÜFER
dc.contributor.authorPetrushkin, Harry
dc.contributor.authorChan, Errol W.
dc.date.accessioned2021-12-10T09:45:58Z
dc.date.available2021-12-10T09:45:58Z
dc.identifier.citationMansour H. A. , Ozdal P. C. , KADAYIFÇILAR S., Tugal-Tutkun I., ESER ÖZTÜRK H., YALÇINDAĞ F. N. , Petrushkin H., Chan E. W. , Belfaiza S., Karadag R., et al., "Familial Mediterranean fever associated frosted branch angiitis, retinal vasculitis and vascular occlusion", EYE, 2021
dc.identifier.issn0950-222X
dc.identifier.othervv_1032021
dc.identifier.otherav_11900d30-b007-4c3a-ac71-aedd6185ce09
dc.identifier.urihttp://hdl.handle.net/20.500.12627/168434
dc.identifier.urihttps://doi.org/10.1038/s41433-021-01822-5
dc.description.abstractObjectives To analyse the entity of retinal vasculitis, including frosted branch angiitis (FBA), or retina vascular occlusion in patients with familial Mediterranean fever (FMF). Methods Retrospective collaborative case series using invitation by email to uveitis specialists around the Mediterranean basin. This series was combined with a literature review. Exclusion criteria included infectious diseases, Behcet's disease or other autoimmune diseases. Results A total of 16 patients (21 eyes) had FMF and retinal vasculitis (FBA 11 patients, mild retinal vasculitis 5 patients). The mean age at onset of vasculitis was 29.5 +/- 13.4 (range 9-62) with a female to male ratio of 9 to 7. In 19 eyes treated with various forms of corticosteroid and/or immunosuppression, the mean initial spectacle-corrected visual acuity improved from 6/194 to 6/10.5 at the last mean follow-up of 29.0 +/- 34.9 months (p < 0.001). The most common FEVR mutations were M680I and M694V. In addition, retinal vascular occlusions included one case of central retinal artery occlusion and one case of branch retinal artery occlusion. Conclusion FBA and milder forms of retinal vasculitis are associated with FMF. Therapy involves an increase in colchicine dosage in early cases, a long period of oral corticosteroid, intravitreal dexamethasone implant or periocular corticosteroid in select cases, and combination therapy with systemic immunosuppression in severe cases. FMF needs to be included in the differential diagnosis of retinal vasculitis.
dc.language.isoeng
dc.subjectOphthalmology
dc.subjectOptometry
dc.subjectHealth Sciences
dc.subjectCerrahi Tıp Bilimleri
dc.subjectGöz Hastalıkları ve Cerrahisi
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectOFTALMOLOJİ
dc.titleFamilial Mediterranean fever associated frosted branch angiitis, retinal vasculitis and vascular occlusion
dc.typeMakale
dc.relation.journalEYE
dc.contributor.departmentAmerican University Of Beirut , ,
dc.contributor.firstauthorID2759315


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