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dc.contributor.authorIŞIKLAN, NURAN
dc.contributor.authorÜSTÜN ALKAN, Fulya
dc.contributor.authorCharehsaz, Mohammad
dc.contributor.authorAYDIN, AHMET
dc.contributor.authorGÜNCÜM, ENES
dc.contributor.authorBAKIREL, Tülay
dc.contributor.authorANLAŞ, Fatma Ceren
dc.date.accessioned2021-12-10T09:46:13Z
dc.date.available2021-12-10T09:46:13Z
dc.identifier.citationGÜNCÜM E., BAKIREL T., ANLAŞ F. C. , IŞIKLAN N., ÜSTÜN ALKAN F., Charehsaz M., AYDIN A., "The screening of the safety profile of polymeric based amoxicillin nanoparticles in various test systems", TOXICOLOGY LETTERS, cilt.348, ss.1-9, 2021
dc.identifier.issn0378-4274
dc.identifier.otherav_12212e5d-2775-401b-bb29-5282c292b09b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/168450
dc.identifier.urihttps://doi.org/10.1016/j.toxlet.2021.05.001
dc.description.abstractNanotechnology-based drugs show superiority over conventional medicines because of increased bioavailability, lower accumulation in non-target tissues, and improved therapeutic index with increased accumulation at target sites. However, it is important to be aware of possible problems related to the toxicity of these products, which have therapeutically superior properties. Accordingly, the present study was designed to investigate the safety profile of amoxicillin nanoparticles (AmxNPs) that we developed to increase the oral bioavailability of amoxicillin (Amx) in poultry. In the first part of the study, the genotoxicity potential of AmxNPs was evaluated using the Ames test and the in vitro comet assay. The results of Ames test showed that none of the tested concentrations of Amx and AmxNPs cause a significant increase in the revertant number of Salmonella typhimurium strains TA98, and TA100, either with or without metabolic activation. Similarly, the comet assay revealed that AmxNPs did not induce DNA damage at any of the concentrations used, whereas high-dose (200 mu g/mL) of Amx caused a significant increase in the percentage of DNA in the tail. In the second part of the study, the toxicity potential of AmxNPs on broilers was investigated by measuring biochemical parameters. In vivo results demonstrated that AmxNps did not cause a significant change in biochemical parameters, whereas Amx increased ALT, glucose, and cholesterol levels at certain sampling times. The obtained findings suggest that AmxNPs could be a safe promising potential drug in drug delivery systems. (C) 2021 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectLife Sciences
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectToxicology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectPhysical Sciences
dc.titleThe screening of the safety profile of polymeric based amoxicillin nanoparticles in various test systems
dc.typeMakale
dc.relation.journalTOXICOLOGY LETTERS
dc.contributor.departmentKırıkkale Üniversitesi , Veteriner Fakültesi , Klinik Öncesi Bilimleri Bölümü
dc.identifier.volume348
dc.identifier.startpage1
dc.identifier.endpage9
dc.contributor.firstauthorID2692559


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