Basit öğe kaydını göster

dc.contributor.authorŞANLI, Ahmet Necati
dc.contributor.authorÖZÇELİK, Mehmet Faik
dc.contributor.authorZENGİN, Abdullah Kağan
dc.contributor.authorULUDAĞ, Server Sezgin
dc.date.accessioned2021-12-10T09:53:39Z
dc.date.available2021-12-10T09:53:39Z
dc.identifier.citationULUDAĞ S. S. , ŞANLI A. N. , ZENGİN A. K. , ÖZÇELİK M. F. , "Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer", AMERICAN SURGEON, 2021
dc.identifier.issn0003-1348
dc.identifier.othervv_1032021
dc.identifier.otherav_1ab28694-9111-47ee-bfe4-233faafb2769
dc.identifier.urihttp://hdl.handle.net/20.500.12627/168721
dc.identifier.urihttps://doi.org/10.1177/0003134821995059
dc.description.abstractBackground This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated. Methods This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients. Results LDH (P < .001), NLR (P < .001), PLR (P < .05), CRP/albumin (P < .01), and neutrophil/albumin (P < .01) were significantly higher, while monocyte count (P < .05) and PNI (P < .01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: -.568, P < .001). Conclusions Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer.
dc.language.isoeng
dc.subjectHealth Sciences
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSurgery
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.titleSystemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer
dc.typeMakale
dc.relation.journalAMERICAN SURGEON
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Cerrahpaşa Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.contributor.firstauthorID2697039


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster