dc.contributor.author | Tascioglu, Didem | |
dc.contributor.author | Genc, Sema | |
dc.contributor.author | Akkaya, Emre | |
dc.date.accessioned | 2021-12-10T09:53:42Z | |
dc.date.available | 2021-12-10T09:53:42Z | |
dc.identifier.citation | Tascioglu D., Akkaya E., Genc S., "The understanding of the immunopathology in COVID-19 infection.", Scandinavian journal of clinical and laboratory investigation, cilt.81, ss.255-263, 2021 | |
dc.identifier.issn | 0036-5513 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_1ad47d90-bf05-46ac-add0-f004ac0ce3ab | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/168724 | |
dc.identifier.uri | https://doi.org/10.1080/00365513.2021.1892817 | |
dc.description.abstract | Coronaviruses belonging to the Coronaviridae family are single-stranded RNA viruses. The entry of SARS-CoV-2 is accomplished via ACE-2 receptors. SARS-CoV-2 infection coactivates both innate and adaptive immune responses. Although SARS-CoV-2 stimulates antibody production with a typical pattern of IgM/IgG, cellular immunity is also impaired. In severe cases, low CD4 + and CD8 + T cell counts are associated with impaired immune functions, and high neutrophil/lymphocyte ratios accompanying low lymphocyte subsets have been demonstrated. Recently, high IFN -alpha/gamma ratios with impaired T cell responses, and increased IL-1, IL-6, TNF-alpha, MCP-1, IP-10, IL-4, IL-10 have been reported in COVID-19 infection. Increased proinflammatory cytokines and chemokines in patients with severe COVID-19 may cause the suppression of CD4 + and CD8 + T cells and regulatory T cells, causing excessive inflammatory responses and fatal cytokine storm with tissue and organ damage. Consequently, novel therapeutics to be developed against host immune system, including blockade of cytokines (IL-6, IL-1, IFN) themselves, their receptors or signaling pathways- JAK inhibitors- could be effective as potential therapeutics. | |
dc.language.iso | eng | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.title | The understanding of the immunopathology in COVID-19 infection. | |
dc.type | Makale | |
dc.relation.journal | Scandinavian journal of clinical and laboratory investigation | |
dc.contributor.department | , , | |
dc.identifier.volume | 81 | |
dc.identifier.startpage | 255 | |
dc.identifier.endpage | 263 | |
dc.contributor.firstauthorID | 2635567 | |